Oral administration of dosage form is the priority for the patients as per its easy administration, economical formulation and various other reasons. Drugs having good absorption in proximal gastrointestinal tract (GIT) part possess bioavailability problem due to less gastric residence time of drug in the stomach. Thus superporous hydrogel (SPH) is a supreme approach to deliver the drug in uppe...

Schizochytrium protein hydrolysate (SPH) was prepared through stepwise enzymatic hydrolysis by alcalase and flavourzyme sequentially. The proportion of hydrophobic amino acids of SPH was 34.71%. The molecular weight (MW) of SPH was principally concentrated at 180-3000 Da (52.29%). SPH was divided into two fractions by ultrafiltration: SPH-I (MW < 3 kDa) and SPH-II (MW > 3 kDa). Besides showing ...

Smoothed particle hydrodynamics (SPH) is a meshfree particle method based on Lagrangian formulation, and has been widely applied to different areas in engineering and science. This paper presents an overview on the SPH method and its recent developments, including (1) the need for meshfree particle methods, and advantages of SPH, (2) approximation schemes of the conventional SPH method and nume...

We present a practical guide to Smoothed Particle Hydro-dynamics (SPH) and its application to astrophysical problems. Although remarkably robust, SPH must be used with care if the results are to be meaningful since the accuracy of SPH is sensitive to the arrangement of the particles and the form of the smoothing kernel. In particular, the initial conditions for any SPH simulation must consist o...

the objective of the present study is to develop and investigate the swelling behavior of ph-sensitive superporous hydrogel (sph) and sph composite (sphc). a novel superporous hydrogel containing poly (methacrylic acid-co-acrylamide) was synthesized from methacrylic acid and acrylamide through the aqueous solution polymerization, using n,n-methylenebisacrylamide as a crosslinker and ammonium pe...

The serum-borne lysophospholipid mediators sphingosine 1-phosphate (Sph-1-P) and lysophosphatidic acid (LPA) have been shown to be released from activated platelets and to act on endothelial cells. In this study, we employed the repeated lipid extraction (under alkaline and acidic conditions), capable of detecting Sph-1-P, LPA, and possibly structurally similar lysophospholipids, whereby a mark...

By comparing a collisionless cosmological N-body simulation (DM) to a smoothed particle hydrodynamics simulation (SPH) with the same initial conditions, we investigate the correspondence between the dark matter subhalos produced by collisionless dynamics and the galaxies produced by dissipative gas dynamics in a dark matter background. When galaxies in the SPH simulation fall into larger groups...

In order to determine whether sphingomyelin (SPH) affects the rate of cholesterol esterification by plasma lecithin-cholesterol acyltransferase (LCAT), we studied the effects of its incorporation in to defined proteoliposome substrates containing phosphatidyl choline (PC), unesterified cholesterol, and apoprotein A-I, on the activity of purified LCAT. Cholesterol esterification was inhibited by...

We report on the metal ion exchange between Co(2+) and CdS-based molecular clusters. These studies demonstrate that exchange into the smaller [Cd4(SPh)10](2-) clusters is facile compared to the larger [Cd10S4(SPh)16](4-) and [Cd17S4(SPh)28](2-) clusters. This trend correlates with the rate of benzenethiolate interconversion and μ-S(2-) and μ-SPh(-) content among the clusters.