The Caenorhabditis elegans F-box protein SEL-10 and its human homolog have been proposed to regulate LIN-12 Notch signaling by targeting for ubiquitin-mediated proteasomal degradation LIN-12 Notch proteins and SEL-12 PS1 presenilins, the latter of which have been implicated in Alzheimer's disease. We found that sel-10 is the same gene as egl-41, which previously had been defined by gain-of-func...

In this study, a hp-version of Finite Element Method (FEM) was applied for forward modeling in image reconstruction of Electrical Impedance Tomography (EIT). The EIT forward solver is normally based on the conventional Finite Element Method (h-FEM). In h-FEM, the polynomial order (p) of the element shape functions is constant and the element size (h) is decreasing. To have an accurate simulatio...

LA-related protein 1 (LARP-1) belongs to an RNA-binding protein family containing a LA motif. Here, we identify LARP-1 as a regulator of sex determination. In C. elegans hermaphrodites, a complex regulatory network regulates the switch from sperm to oocyte production. We find that simultaneous depletion of larp-1 and the Nanos homologue nos-3 results in germline masculinization. This phenotype ...

The purpose of this paper is to present an adaptive FEM-BEM coupling method that is valid for both twoand three-dimensional elasto-plastic analyses. The method takes care of the evolution of the elastic and plastic regions. It eliminates the cumbersome of a trial and error process in the identification of the FEM and BEM sub-domains in the standard FEM-BEM coupling approaches. The method estima...

In Electro- (EEG) and Magnetoencephalography (MEG), one important requirement of source reconstruction is the forward model. The continuous Galerkin finite element method (CG-FEM) has become one of the dominant approaches for solving the forward problem over the last decades. Recently, a discontinuous Galerkin FEM (DG-FEM) EEG forward approach has been proposed as an alternative to CG-FEM (Engw...

Caenorhabditis elegans and Caenorhabditis briggsae are both self-fertile hermaphroditic nematodes that evolved independently from male/female ancestors. In C. elegans, FEM-1, FEM-2, and FEM-3 specify male fates by promoting proteolysis of the male-repressing transcription factor, TRA-1. Phenotypes of tra-1 and fem mutants are consistent with this simple linear model in the soma, but not in the ...

In this paper, the second order boundary value problem −∇·(A(x, y)∇u) = f is discretized by the Finite Element Method using piecewise polynomial functions of degree p on a triangular mesh. On the reference element, we define integrated Jacobi polynomials as interior ansatz functions. If A is a constant function on each triangle and each triangle has straight edges, we prove that the element sti...

Finite element method (FEM) has been widely used as a useful numerical method that can analyze complex engineering problems in electro-magnetics, mechanics, and others. CEMTool, which is similar to MATLAB, is a command style design and analyzing package for scientific and technological algorithm and a matrix based computation language. In this paper, we present new 3D FEM package in CEMTool env...

FEM performance enhancement achieved by use of r.f. prebunching of the e-beam in the FEM developed at TAU was investigated theoretically and experimentally. For FEM operation as an oscillator, use of e-beam prebunching enables stable, coherent, high output power throughout the r.f. output pulse at any selected oscillator eigenfrequency for which the net gain is above unity. Prebunching enables ...

Hybrid FEM/MoM methods combine the finite element method (FEM) and the method of moments (MoM) to model inhomogeneous unbounded problems. These two methods are coupled by enforcing the continuity of tangential fields on the boundary that separates the FEM and MoM regions. When modeling complex geometries with many elements on the boundary, the MoM part of the problem is the bottleneck of the hy...