Prior literature documents that the Sharpe ratio (SR) generates biases in performance evaluation if returns distribution deviates from normal because SR is derived under mean-variance model with strict assumption of either quadratic preferences or customarily distributed returns. When return distributions deviate normality, it may lead to unreasonable results. Therefore, this study examines whi...

Equine protozoal myeloencephalitis (EPM) is the most commonly diagnosed infectious neuro-degenerative condition in horses and neuroinflammation is present in all definitively diagnosed cases. Historically EPM is difficult to treat. Polyneuritis equi (cauda equina neuritis) is a rarely recognized noninfectious, chronic relapsing, peripheral neurodegenerative disorder in horses. We propose that p...

This writing aims to find out whether PT EPM has previously implemented tax planning of income owed its company, know the strategy that can be applied EPM, and influence when implementing (tax planning) income. Primary data used in form interviews is get company information not listed documents, then secondary / loss statements annual returns Agency 2019. Data analysis methods use quantitative ...

We read with great interest the article by Larghi et al. [1], a multicenter cohort study about prevalence and risk factors of extrapancreatic malignancies (EPMs) in patients with intraductal papillary mucinous neoplasm (IPMN) of the pancreas. They concluded that their prevalence was high, especially for colorectal carcinoma, renal cell and thyroid cancers. IPMN harbored some genetic mutations i...

PhD. Postgraduate student, Department of Pediatrics, Division of Pediatric Gastroenterology, Universidade Federal de São Paulo — Escola Paulista de Medicina (Unifesp-EPM), São Paulo, Brazil. PhD. Attending physician, Department of Pediatrics, Division of Pediatric Gastroenterology, Universidade Federal de São Paulo — Escola Paulista de Medicina (Unifesp-EPM), São Paulo, Brazil. PhD. Professor, ...

Rats exposed to an elevated plus maze (EPM) with four open arms display antinociception while on the maze and hyperalgesia immediately upon removal. Little is known about the neural mechanisms underlying EPM-induced antinociception and the subsequent hyperalgesia except that the antinociception is not mediated by endogenous opioids. The objective of the present study was to test the hypothesis ...

MD. Physician in the Breast Group of the Department of Gynecology, Universidade Federal de São Paulo — Escola Paulista de Medicina (Unifesp-EPM), São Paulo, Brazil. MD. Physician in the Department of Gynecology, Universidade Federal de São Paulo — Escola Paulista de Medicina (Unifesp-EPM), São Paulo, Brazil. MD, PhD. Chief professor of Gynecology, Mastology Sector, Department of Gynecology, Uni...

There is a growing trend toward electronic performance monitoring (EPM) to track the performance of workers engaged in computer-based tasks. Despite the possible productivity advantages of this approach to work management, the use of EPM may produce stress through work overload, negative computer feedback, loss of incentive pay and threat of job loss. These stress effects are most likely to occ...

Equine protozoal myeloencephalitis (EPM) can be caused by either of 2 related protozoan parasites, Sarcocystis neurona and Neospora hughesi, although S. neurona is the most frequent etiologic pathogen. Horses are commonly infected, but clinical disease occurs infrequently; the factors influencing disease occurrence are not well understood. Risk factors for the development of EPM include the pre...