The systematic use of antivitamin K anticoagulants (AVK) as rodenticides caused the selection of rats resistant to AVKs. The resistance is mainly associated to genetic polymorphisms in the Vkorc1 gene encoding the VKORC1 enzyme responsible for the reduction of vitamin K 2,3-epoxide to vitamin K. Five major mutations, which are responsible for AVK resistance, have been described. Possible explan...

Symmetric key cryptography has been a hot topic because of exchange of secure communication through various networks ligand Investigation of reversible XOR like function for symmetric key cryptography has been a big challenge. Moreover it is also desired that the reversible XOR function must be as efficient as traditional XOR. In the literature related to Automatic Variables Key, Fibonacci-Q ma...

This paper shows how mathematical methods can be implemented to formulate guidelines for clinical testing and monitoring of HIV/AIDS disease. First, a mathematical model for HIV infection is presented which the measurement of the CD4T cells and the viral load counts are needed to estimate all its parameters. Next, through an analysis of model properties, the minimal number of measurement sample...

Control of rodent pests worldwide relies heavily on the use of rodenticides. In the 40s’, O’Connor (1948) isolated and first suggested the use of dicoumarol (a naturally occurring substance responsible for the “sweet clover disease” in cattle) as a rodenticide. In the early 50s’, anticoagulant rodenticides (warfarin and later indane-dione derivatives) replaced the acute poisons with great succe...

Abstract Background and Aims Direct oral anticoagulants (DOACs) are a well-known alternative to conventional antagonist of vitamin-K (avK) have emerged as the preferred choice due their safety efficacy profile. However, immune modulating drugs cyclosporine tacrolimus, commonly used for transplant recipients, may interfere with DOACs pharmacokinetic. Our study evaluates profile direct compared a...

Background and aims Few studies discuss the prevalence of oral anticoagulation therapy (OAT) in clinical practice, despite their increasing use worldwide. In America, studies established that 20% to 80% of the patients with indication benefit from OAT. In Romania, there is no data regarding the utilization of oral anticoagulants. Thus, this study aims to determine the trends of OAT. Methods W...

A Magyar Nemzeti Múzeum Régészeti Örökségvédelmi Igazgatósága az M30-as számú gyorsforgalmi út Miskolcot Košice/Kassával összekötő szakaszának építési munkálatai során 2018. augusztus 28. és szeptember 19. között egy újkőkori település részleges feltárását végezte el Novajidrány, Szőlő-alja II. lelőhelyen. Az előzetes feldolgozás alapján előkerült mintegy 86, településhez, illetve temetkezéshez...

The Superpave gyratory compactor (SGC) is used to compact asphalt specimens for mixture testing in the Superpave system. Five companies currently manufacture SGCs for use in the United States, offering a total of eight different models. Each model employs a unique method of setting, inducing, and maintaining the specified angle of gyration. Calibration systems are required for each device for t...