The molecular mechanisms of the DNA mismatch repair (MMR) system have been uncovered over the last decade, especially in prokaryotes. The results obtained for prokaryotic MMR proteins have provided a framework for the study of the MMR system in eukaryotic organisms, such as yeast, mouse and human, because the functions of MMR proteins have been conserved during evolution from bacteria to humans...

BACKGROUND The identification of mismatch-repair (MMR) defective colon cancer is clinically relevant for diagnostic, prognostic and potentially also for treatment predictive purposes. Preselection of tumors for MMR analysis can be obtained with predictive models, which need to demonstrate ease of application and favorable reproducibility. METHODS We validated the MMR index for the identificat...

Animal metabolic rate is variable and may be affected by endogenous and exogenous factors, but such relationships remain poorly understood in many primitive fishes, including members of the family Acipenseridae (sturgeons). Using juvenile lake sturgeon (Acipenser fulvescens), the objective of this study was to test four hypotheses: 1) A. fulvescens exhibits a circadian rhythm influencing metabo...

background: maternal mortality (mm) is an avoidable death andthere is national, international and political commitment to reduceit. the objective of this study is to examine the relation of mm tosocioeconomic factors and its inequality in iran’s provinces at anecologic level.methods: the overall mm from each province was considered for3 years from 2004 to 2006. the five independent variables wh...

Control 16 Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline Saline MMR 15 Saline Saline Saline Saline MMR MMR Saline Saline Saline Saline Saline Saline Saline Saline Saline TCV 12 Hep B Hep B Hep B Hep B Saline Saline DTaP DTaP DTaP DTaP DTaP Hib Hib Hib Hib 1990s Primate 12 Hep B Hep B Hep B Hep B MMR MMR DTaP DTaP DTaP DTaP DTaP Hib Hib Hib Hib...

Midgut malrotation (MMR) is a congenital anomaly referring to either nonrotation or incomplete rotation of the primitive intestinal loop around the axis of the superior mesenteric artery during fetal development. Adult MMR is rare and majority of MMR in adults remains asymptomatic throughout life. The increasing use of diagnostic imaging for acute abdominal pain will lead to more incidental rec...

This study focused on the question of how the DNA mismatch repair (MMR) system and p53 interact to maintain genomic integrity in the presence of the mutagenic stress induced by hydrogen peroxide (H(2)O(2)). The cytotoxic and mutagenic effects of H(2)O(2) were compared in four colon carcinoma sublines: HCT116, HCT116/E6, HCT116+ch3, and HCT116+ch3/E6, representing MMR(-)/p53(+), MMR(-)/p53(-), M...

Vibration energy harvesting technology can capture ambient forms. Using an shock absorber (EHSA) is one of the methods to achieve this function. The EHSA with mechanical motion rectifier (MMR) has bifurcation, which improve performance and reduce impact between gears. However, bifurcation makes it difficult quantitatively predict vibrational dissipation MMR−EHSA. Evaluating MMR−EHSA during desi...