نتایج جستجو برای: دی اکسیژناز ido
تعداد نتایج: 20902 فیلتر نتایج به سال:
In patients with hepatitis C virus (HCV) infection, enhanced activity of indoleamine-2,3-dioxygenase 1 (IDO) has been reported. IDO - a tryptophan-catabolizing enzyme - has been considered as both an innate defence mechanism and an important regulator of the immune response. The molecular mechanism of IDO induction in HCV infection and its role in the antiviral immune response remain unknown. U...
Dendritic cells (DCs) can induce tolerance or immunity. We identified and characterized an IDO-expressing and an IDO-negative human DC population after stimulation by various proinflammatory stimuli. IDO expression was strongly dependent on the maturation status of the cells (CD83-positive cells only). The two DC subpopulations remained IDO positive and IDO negative, respectively, over a time p...
بی فنیل های پلی کلرینه شده (pcbs)، ترکیبات حلقوی کلرداری هستند که به دلیل خواصی چون مقاومت به حرارت و پایداری، در سطح گسترده در دهه های 1930 تا 1980 در صنایع گوناگون مورد استفاده قرار گرفتند. همین ویژگی پایداری و مقاوت به تجزیه شدن همراه با اثرات مضری که بر سلامت انسان می گذارند، سبب شد که تولید آن ها از دهه 1980 میلادی متوقف شود. در حال حاضر، آلودگی آب ها و خاک های سراسر جهان به pcbs، یکی از م...
BACKGROUND The enzyme indoleamine 2,3-dioxygenase (IDO) contributes to immune tolerance in a variety of settings. In cancer IDO is expressed within the tumor itself as well as in antigen-presenting cells in tumor-draining lymph nodes, where it endorses the establishment of peripheral immune tolerance to tumor antigens. Recently, we described cytotoxic CD8(+) T-cell reactivity towards IDO-derive...
Indoleamine-2,3-dioxygenase (IDO) inhibitors have entered clinical trials based on their ability to restore anti-tumor immunity in preclinical studies. However, the mechanisms leading to constitutive expression of IDO in human tumors are largely unknown. Here we analyzed the pathways mediating constitutive IDO expression in human cancer. IDO-positive tumor cells and tissues showed basal phospho...
در این پروژه یک سری جدید از لیگاندهای آمینوبیس(فنولی) با استفاده از 2-(آمینومتیل)پیریدین و فنول های 2،4-استخلاف دار مختلف شامل، 2،4-دی-برموفنول (h2lampb)، 2-ترشیو-بوتیل-4-متیل فنول(h2lampbm)، 2-ترشیو-بوتیل-4-متوکسی فنول (h2lampome) و 2،4-دی-متیل فنول (h2lampme) سنتز و شناسایی شدند. علاوه بر این در سنتز کمپلکس ها از لیگاند h2lampc که با استفاده از 2،4-دی-کلروفنول سنتز شده است، نیز استفاده شده اس...
objective: in this study, we sought to better understand the immunoregulatory function of stem cells derived from human exfoliated deciduous teeth (shed). we studied the role of the interferon gamma (ifn-γ)-indoleamine 2,3-dioxygenase (ido)-axis in immunoregulation of shed compared to bone marrow derived mesenchymal stem cells (bmmscs) under the same conditions. materials and methods: in this c...
The indoleamine 2,3-dioxygenase-(IDO-) mediated microenvironment plays an important role in tumor immune escape. However, the inhibitory effects of IDO on the CD8(+) tumour-infiltrating lymphocytes (CD8(+) TILs) in esophageal squamous cell carcinoma (ESCC) have not been clarified yet. Here, we found that the level of IDO expression in ESCC tumor specimens correlated with a reduction in the numb...
Preeclampsia is a cardiovascular disorder of late pregnancy that is, commonly characterized by hypertension, renal structural damage and dysfunction, and fetal growth restriction. Prevailing etiologic models of this disorder include T-cell dysfunction as an initiating cause of preeclampsia. Indoleamine 2,3-dioxygenase (IDO), an enzyme that mediates the conversion of tryptophan to kynurenine, ha...
Indoleamine 2,3 Dioxygenase (IDO) Expression and Activity in Relapsing- Remitting Multiple Sclerosis
BACKGROUND Interferon gamma (IFN-γ) production induces the transcription of indoleamine 2,3 dioxygenase (IDO) resulting in the reduction of T-cell activation and proliferation through the depletion of tryptophan and the elicitation of Treg lymphocytes. IDO was shown to be involved in the pathogenesis of autoimmune diseases; we investigated whether changes in IDO gene expression and activity cou...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید