نتایج جستجو برای: دیگوکسین digoxin

تعداد نتایج: 3205  

Journal: :journal of cardio-thoracic medicine 0
alireza sharifian attar anesthesiologist, cardio- thoracic surgery & transplant research center, emam reza hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran reza jalaeian taghaddomi anesthesiologist,endoscopic and minimally invasive surgery research center, ghaem hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran mohsen moohebati cardiologist, department of cardiology, ghaem hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran reza bagheri thoracic surgery,cardio- thoracic surgery & transplant research center, emam reza hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran elahe hosseinian resident of anesthesiology, department of anesthesia, ghaem hospital, faculty of medicine, mashhad university of medical sciences, mashhad, ira

introduction: pneumonectomy is the standard treatment of lung cancer, even though patients should undergo several evaluations before surgery; deterioration of cardiopulmonary function after pulmonary resection is inevitable. we have evaluated the effects of digoxin on the improvement of right ventricular function and prevention of probable complications after lung resection surgery. materials a...

Journal: :Circulation research 1984
N J Warner J T Barnard E B Leahey T J Hougen J T Bigger T W Smith

To study the relationship of the serum digoxin concentration to the digoxin effect on monovalent cation transport during the quinidine-digoxin interaction, we used radiolabeled rubidium to measure monovalent cation active transport in myocardial biopsy samples from dogs. In a preliminary study, we showed that quinidine did not affect rubidium uptake by myocardial samples from intact dogs. Then,...

2005
THOMAS W. SMITH

Controversy persists regarding the role of tubular reabsorption and secretion in the renal handling of digoxin. To determine the effect of reduction in renal perfusion pressure and blood flow on digoxin clearance during acute and chronic digoxin administration, renal clearances of digoxin and inulin were measured in pentobarbital-anesthetized dogs before and after repeated unilateral renal arte...

Journal: :Archives of pathology & laboratory medicine 2007
Amitava Dasgupta Amanda Peterson Alice Wells Jeffrey K Actor

CONTEXT Ashwagandha, a popular Ayurvedic medicine, is now available in the United States. Alkaloids found in this herb have structural similarity with digoxin. OBJECTIVE To study potential interference of Ashwagandha with serum digoxin measurement by immunoassays. Potential interference was also investigated with immunoassays for 11 other commonly monitored drugs. In addition, interaction of ...

Journal: :British medical journal 1972
E M Baylis M S Hall G Lewis V Marks

An investigation into the relations between the daily dose of digoxin, drug regimen, serum digoxin concentration, and creatinine and digoxin clearance was carried out in a group of elderly ambulant patients in domiciliary practice. Moderate to severe impairment of renal function was found both in patients taking digoxin and in elderly control subjects. Plasma digoxin levels were not related to ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2004
Vincent Castagne Laurence Bonhomme-Faivre Saik Urien Makram Ben Reguiga Mireille Soursac Francois Gimenez Robert Farinotti

P-glycoprotein (P-gp) is an ATP-dependent efflux membrane transporter involved in many drug pharmacokinetics in humans. Decreasing its expression could enhance the bioavailability of substrates as digoxin. We have recently found that human recombinant interleukin-2 (rIL2) in vivo decreases P-gp expression in intestine and brain of mice and modifies oral digoxin pharmacokinetics. The aim of the ...

Journal: :British heart journal 1972
A Redfors

was found between digoxin dosage and plasma digoxin concentration. Patients who did not develop symptoms of digitalis intoxication until at high doses showed a slower increase ofplasma levels. At the first appearance of toxic symptoms 'steady state' values of about 6 ng digoxin/ml werefound. Excluding one divergent patient, a close inverse correlation wasfound between plasma digoxin concentrati...

Journal: :The Journal of antimicrobial chemotherapy 2002
P Zapater S Reus A Tello D Torrús M Pérez-Mateo J F Horga

The study was a prospective observational trial carried out to assess the clarithromycin-digoxin interaction in elderly patients chronically taking digoxin. Digoxin concentrations were determined before and after concomitant treatment with clarithromycin. A Bayesian approach was used to calculate digoxin pharmacokinetics. In the seven patients who were studied there was a significant increase i...

Journal: :Circulation 1999
M F Fromm R B Kim C M Stein G R Wilkinson D M Roden

BACKGROUND Although quinidine is known to elevate plasma digoxin concentrations, the mechanism underlying this interaction is not fully understood. Digoxin is not extensively metabolized, but it is known to be transported by the drug efflux pump P-glycoprotein, which is expressed in excretory tissues (kidney, liver, intestine) and at the blood-brain barrier. Accordingly, we tested the hypothesi...

1999
Martin F. Fromm Richard B. Kim Michael Stein Dan M. Roden

Background—Although quinidine is known to elevate plasma digoxin concentrations, the mechanism underlying this interaction is not fully understood. Digoxin is not extensively metabolized, but it is known to be transported by the drug efflux pump P-glycoprotein, which is expressed in excretory tissues (kidney, liver, intestine) and at the blood-brain barrier. Accordingly, we tested the hypothesi...

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