An impairment in lymphocyte response to mitogen stimulation, a correlate of cell-mediated immunity, has been reported in patients with depressive illness. To investigate whether such impairment in lymphocyte function is related to excessive secretion of cortisol, an immunosuppressive hormone, we compared mitogen-induced lymphocyte proliferation in three groups of subjects: depressed patients wi...

Laboratory of Experimental Neurology and Neurophysiology/DFF/UFC and Institute of Biomedicine of the Brazilian Semiarid/ INCT/CNPq: MD, MSc; MD, PhD, Full Professor of Neurology and Neurophysiology/DFF/UFC; MD, Medical Doctor of the Brasília Base Hospital; MSc, PhD, Associate Professor of the Medicine Course of the Christus Faculty; DVM; DVM, PhD, Professor of the Superior School of Agriculture...

This study aimed to evaluate the survival rate of microorganisms within different antiseptic formulations - povidone-iodine (PVP-I) and chlorhexidine (CHX) - after intentional contamination, and to establish the minimum care necessary to ensure sterilization of non-disposable antiseptic solution containers. A laboratory study was performed with 180 antiseptic containers, which were contaminated...

1. Especialista em Cirurgia Cardiovascular, mestre em Avaliação de Políticas Públicas pela Universidade Federal do Ceará (UFC), chefe de Cirurgia Cardiovascular Pediátrica do Hospital Messejana, Fortaleza, CE, Brasil. 2. Doutora em Enfermagem pela Universidade Federal do Ceará, docente do Curso de Mestrado Profissional em Avaliação de Políticas Públicas pela UFC, Fortaleza, CE, Brasil. 3. Docen...

1 Pathology Department, Universidade Federal do Ceará – UFC, Fortaleza, CE, Brazil 2 Department of Clinical Analysis and Toxicology, Universidade Federal do Ceará – UFC, Fortaleza, CE, Brazil 3 Department of Clinical Medicine, Universidade Federal do Ceará – UFC, Fortaleza, CE, Brazil Alana Jocelina Montenegro de Castro1 Romelia Pinheiro Gonçalves Maria Helena da Silva Pitombeira3 Visceral leis...

BACKGROUND Cabergoline is a long-acting dopamine receptor agonist used to treat prolactinomas. Identification of D(2) receptors in corticotroph tumors led to clinical trials of cabergoline therapy in limited cases of Nelson's syndrome, ectopic ACTH-secreting tumors, and recently Cushing's disease (CD). OBJECTIVE To evaluate the long-term efficacy of cabergoline monotherapy in patients with CD...

Measuring salivary cortisol is both convenient and non-invasive for patients; however, its usefulness as a marker for monitoring medical therapy has not yet been established. The aim of this study was to assess the utility of multiple salivary cortisol measurements in patients with Cushing's syndrome (CS) during medical therapy. Six patients with CS (three with cortisol-secreting adrenocortical...

Measuring salivary cortisol is a simple, convenient and accurate technique with potential value in monitoring patients with hypercortisolism. This analysis reports changes in late-night salivary cortisol (LNSC) during a 12-month, multicentre, Phase III study of patients with Cushing's disease who were randomized to pasireotide 600 or 900 μg sc bid. LNSC assessment was an exploratory objective b...

To the Editor: Urinary free cortisol is largely accepted as an accurate means of assessing daily cortisol secretion. A more precise definition of this marker should be “urinary free corticoids” (UFCs), because all competitive binding assays overestimate free cortisol in urine (1 ). Recently, it has been argued that urine volume may be a confounding factor because high fluid intake has been repo...

787 Nutritive value of three organisms from mangrove ecosystem: Ucides cordatus (Linnaeus, 1763), Mytella sp. (Soot-Ryen, 1955) and Crassostrea rhizophorae (Guilding, 1828) Carvalho, AFU.*, Farias, DF., Barroso, CX., Sombra, CML., Silvino, AS., Menezes, MOT., Soares, MO., Fernandes, DAO. and Gouveia, ST. Departamento de Biologia, Universidade Federal do Ceará – UFC Av. Mister Hull, s/n, Campus ...