Apolipoprotein AI (apo AI) is the major protein component of the serum high-density lipoprotein (HDL) particles. The antiatherogenic properties of apo AI alone or as part of HDL and their inverse correlation with the incidence of coronary heart disease underlie the clinical importance of the protein. A detailed understanding of the mechanisms by which apo AI is regulated will help us develop ne...

دیکچ ه باس فده و هق : ب یناوجون نارود رد هیذغت تیعضو یسررب ه زا ،نارود نیا رد یراتفر و یکیزیف تارییغت تعسو لیلد ب تیمها ه تسا رادروخرب ییازس . یذغتءوس نزو هفاضا ،یرغلا ،یقاچ زا معا ه هیذغت یدق هاتوک و یناوـجون نارود رد یا صخاش نییعت رد ب نارود رد یرامیب عون و ریم و گرم یاه م یلاسگرز ؤ تـسا رث . لماوـع تاـعلاطم زا یرایسـب لـثم ی هتسناد طبترم هیذغت عضو اب بسانم ییاذغ تاداع داجیا و یتفایرد یفاضا...

OBJECTIVE Anderson disease is a rare inherited lipid malabsorption syndrome associated with hypocholesterolemia and linked to SAR1B mutations. The aim of this article was to analyze the mechanisms responsible for the low plasma apolipoprotein Apo-B100 and Apo-AI in 2 patients with Anderson disease. METHODS AND RESULTS A primed constant infusion of (13)C-leucine was administered for 14 hours t...

In order to ascertain the most effective index for predicting coronary sclerosis, the concentration of lipids, lipoproteins, and apoproteins in serum were determined in 45 males aged over 44 with angiographically diagnosed effort angina and in 153 male controls aged over 44 without ischemic heart disease (IHD) on physical examination. The results of our study are summarized as follows. 1) Alcoh...

The plasma high-density lipoproteins (HDL, rho 1.085-1.21 g/ml) of rainbow trout (Salmo gairdneri) have been shown to contain large amounts of apolipoprotein (apo) AI (Mr 28,000) and several other apolipoproteins of Mr less than 14,000 (apo C-like) and of Mr 37,000-38,000, 44,000-45,000 and 53,000-54,000. Comparison of apo AI from trout and human HDL shows them to be similar in Mr and to have s...

These studies were undertaken to determine the kinetic characteristics of high density lipoprotein (HDL) apo AI and cholesteryl ester transport in the hamster in vivo. Saturable HDL apo AI transport was demonstrated in the kidneys, adrenal glands, and liver. Saturable HDL cholesteryl ester transport was highest in the adrenal glands and liver. In the liver and adrenal glands, maximal transport ...

We studied the heterogeneity of high-density lipoproteins (HDL) in plasma of 110 subjects, using three different methods: (a) gradient gel electrophoresis (GGE); (b) electroimmunoassay, to measure the concentration of lipoprotein particles containing apoprotein (apo) AI but no apo-AII (LP AI); and (c) cholesterol esterification rate (FERHDL) in very-low- and low-density lipoprotein-depleted pla...

To better understand the tissue-specific expression of the human apolipoprotein (apo)AI gene, we performed a detailed analysis of the pattern of methylation of the gene in various human adult and embryonic tissues and in tissues of transgenic mice harboring the human apo-AI gene. In addition, the gene was analyzed also in liver and intestine-derived human cell lines (HepG2 and Caco2, respective...

Dyslipidemia is found to be associated with the initiation and progression of diabetic retinopathy (DR). Modifications of lipoproteins by glycation and oxidation and the variations in the size distributions of lipoprotein particles are not reflected in conventional lipid profiles. This study was conducted to know if the measurements of apolipoprotein AI (apo AI) and apolipoprotein B (apo B) may...