BACKGROUND MST-4 and TRAF-6 are involved in the regulation of inflammatory and immune responses. However, whether they participate in the pathogenesis of Graves' disease (GD) has not yet been reported. Therefore, the purpose of this study was to investigate the expression of MST-4 and TRAF-6 in the peripheral blood of patients with GD to understand their role in the pathogenesis of GD. METHOD...

We have examined the involvement of components of the interleukin-1 (IL-1) signaling pathway in the transactivation of gene expression by the p65 subunit of NF-kappaB. Transient transfection of cells with plasmids encoding wild-type MyD88, IL-1 receptor-associated kinase 1 (IRAK-1), and TRAF-6 drove p65-mediated transactivation. In addition, dominant negative forms of MyD88, IRAK-1, and TRAF-6 ...

Upon recognition of viral infection, RIG-I and Helicard recruit a newly identified adapter termed Cardif, which induces type I interferon (IFN)-mediated antiviral responses through an unknown mechanism. Here, we demonstrate that TRAF3, like Cardif, is required for type I interferon production in response to intracellular double-stranded RNA. Cardif-mediated IFNalpha induction occurs through a d...

The paper summarizes a project to increase the sense of presence within a driving simulator while interacting with autonomous trafŽc. The project sought to model natural variations in ambient trafŽc to emulate identiŽable driving styles for different categories of driver. Probability distributions combined with decision histories were employed to characterize speed choice while providing a mech...

objective(s): human and animal studies have shown a close relationship between obesity and asthma severity. here, we examined the effects of diet-induced obesity (dio) on the expression levels of il-1β, irak-1 and traf-6 mrna in male wistar rats tracheal after sensitization with ovalbumin (ova). materials and methods:twenty male wistar rats divided to four groups, included, control group with n...

OBJECTIVE Intracellular tumor necrosis factor receptor-associated factors (TRAFs) translocation to lipid rafts is a key element in CD40-induced signaling. The purpose of this study was to investigate the influence of anthocyanin on CD40-mediated proinflammatory events in human endothelial cells and the underlying possible molecular mechanism. METHODS AND RESULTS Treatment of endothelial cells...

The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of intracellular proteins were originally identified as signaling adaptors that bind directly to the cytoplasmic regions of receptors of the TNF-R superfamily. The past decade has witnessed rapid expansion of receptor families identified to employ TRAFs for signaling. These include Toll-like receptors (TLRs), NOD-like re...

This paper focuses on the modeling and performance analysis for IPv6 traf®c with multi-class QoS in virtual private networks (VPN). The multi-class QoS is implemented on differentiated service basis using priority scheme of 4 bits de®ned in the packet header of IPv6. A VPN-enabled IP router is modeled as a tandem queuing system in which each output link consists of two parallel priority output ...

TraF, an essential component of the conjugative transfer apparatus of the broad-host-range plasmid RP4 (IncP), which is located at the periplasmic side of the cytoplasmic membrane, encodes a specific protease. The traF gene products of IncP and Ti plasmids show extensive similarities to prokaryotic and eukaryotic signal peptidases. Mutational analysis of RP4 TraF revealed that the mechanism of ...

Input Queued(IQ) switches have been very well studied in the recent past. The main problem in the IQ switches concerns scheduling. The main focus of the research has been the £xed length packet-known as cells-case. The scheduling decision becomes relatively easier for cells compared to the variable length packet case as scheduling needs to be done at a regular interval of £xed cell time. In rea...