نتایج جستجو برای: جهش jak2

تعداد نتایج: 7772  

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Yansheng Hao Bjoern Chapuy Stefano Monti Heather H Sun Scott J Rodig Margaret A Shipp

PURPOSE Classical Hodgkin lymphoma (cHL) and primary mediastinal large B-cell lymphoma (MLBCL) share similar histologic, clinical, and genetic features. In recent studies, we found that disease-specific chromosome 9p24.1/JAK2 amplification increased JAK2 expression and activity in both cHL and MLBCL. This prompted us to assess the activity of a clinical grade JAK2 selective inhibitor, fedratini...

Background and Objective: Janus kinase 2 (JAK2) and Myeloproliferative Leukemia (MPL) mutations are confirmatory indicators for Myeloproliferative Neoplasm (MPN). The current study was performed to determine the frequency of MPL mutation in MPN patients without JAK2 mutation, in order to assign MPL mutation frequency in North-East of Iran.Methods: Total o...

Gedik, Habip, Yokus, Osman,

Background: We aimed to investigate the etiologic causes and the existence of Janus kinase 2  mutation (JAK2) in cases with thrombocytosis. Methods: In this retrospective study, patients, who were admitted to hematology clinic with thrombocytosis between 2013 and 2015, were investigated in terms of the etiological causes of thrombocytosis and the existence of JAK2 mutation. Results: We retrospe...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2012
Zohreh Hosseinzadeh Shefalee K Bhavsar Florian Lang

JAK2 (Janus kinase-2) is activated by cell shrinkage and may thus participate in cell volume regulation. Cell volume regulatory ion channels include the small conductance Cl(-) channels ClC-2. The present study thus explored whether JAK2 influences ClC-2 activity. To this end, ClC-2 was expressed in Xenopus oocytes with or without wild type JAK2, active (V617F)JAK2 or inactive (K882E)JAK2 and t...

Journal: :The Journal of biological chemistry 2008
Lin Jiang Zhiqin Li Liangyou Rui

Leptin controls body weight by activating the long form of the leptin receptor (LEPRb). Janus kinase 2 (JAK2) is associated with LEPRb and autophosphorylates in response to leptin. JAK2 also phosphorylates LEPRb, STAT3, and multiple other downstream molecules. Surprisingly, here we show that JAK2 is not required for leptin stimulation of STAT3 phosphorylation. Leptin time- and dose-dependently ...

2013
Nicole M. Anderson Mojib Javadi Elizabeth Berndl Zorana Berberovic Monica L. Bailey Kai Huang Ann M. Flenniken Lucy R. Osborne S. Lee Adamson Janet Rossant Christin Carter-Su Chen Wang Kelly M. McNagny Robert F. Paulson Mark D. Minden William L. Stanford Dwayne L. Barber

Utilizing ENU mutagenesis, we identified a mutant mouse with elevated platelets. Genetic mapping localized the mutation to an interval on chromosome 19 that encodes the Jak2 tyrosine kinase. We identified a A3056T mutation resulting in a premature stop codon within exon 19 of Jak2 (Jak2(K915X)), resulting in a protein truncation and functionally inactive enzyme. This novel platelet phenotype wa...

Journal: :international journal of hematology-oncology and stem cell research 0
mehrdad payande medical biology research center, kermanshah university of medical sciences, kermanshah, iran mohammad erfan zare medical biology research center, kermanshah university of medical sciences, kermanshah, iran; student saber ghanbari haji shure student of medical lab sciences in research committee, kermanshah university of medical sciences, kermanshah, iran farhad shaveisi zadeh medical genetics department, faculty of medicine, shahid beheshti university of medical sciences and

myeloproliferative neoplasms (mpns) such as polycythemia vera, essential thrombocythemia, primary myelofibrosis and chronic myeloid leukemia have too similar and accurate way to differentiate their is study of genetic disorders in these patients. philadelphia chromosome is a sure way to definitively diagnose cml. recently, jak2v617f mutation introduced as a diagnostic marker for other myeloprol...

2010
Jixin Zhong Ping Yang Kenjiro Muta Robert Dong Mario Marrero Feili Gong Cong-Yi Wang

Given the importance of Jak2 in cell signaling, a critical role for Jak2 in immune cells especially dendritic cells (DCs) has long been proposed. The exact function for Jak2 in DCs, however, remained poorly understood as Jak2 deficiency leads to embryonic lethality. Here we established Jak2 deficiency in adult Cre(+/+)Jak2(fl/fl) mice by tamoxifen induction. Loss of Jak2 significantly impaired ...

Journal: :international journal of hematology-oncology and stem cell research 0
fatemeh nadali pathology department, school of medicine, isfahan university of medical sciences, isfahan, iran sh ferdowsi school of allied health sciences, tehran university of medical sciences, tehran, iran p karimzadeh school of allied health sciences, tehran university of medical sciences, tehran, iran bahram chahardouli hematology-oncology and bmt research center, shariati hospital, tehran university of medical science, tehran, iran n einollahi school of allied health sciences, tehran university of medical sciences, tehran, iran sa mousavi hematology-oncology and bmt research center, shariati hospital, tehran university of medical science, tehran, iran

jak2 is a tyrosine kinase that plays an important role in the signaling pathways of many hematopoietic growth factor receptors. a single acquired point mutation – v617f – in jak2 occurs in the great majority of patients with polycythemia vera (pv) and approximately half of the patients with idiopathic myelofibrosis (imf) or essential thrombocythemia (et). in contrast, the jak2-v617f mutation is...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
L Rui C Carter-Su

Janus kinases (JAKs) are cytoplasmic tyrosine kinases critical for signaling by growth hormone (GH) and many other ligands that bind to members of the cytokine receptor superfamily. SH2-Bbeta was previously identified as a JAK2-interacting protein that is tyrosyl phosphorylated in response to GH and other cytokines that activate JAK2. In this study, we examined whether SH2-Bbeta alters the acti...

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