Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR). Newly developed "correctors" such as lumacaftor (VX-809) that improve CFTR maturation and trafficking and "potentiators" such as ivacaftor (VX-770) that enhance channel activity may provide important advances in CF therapy. Although VX-770 has demonstrated substantial clinical efficacy in the small...

Many pion decays of ρ(770) and ω(782) mesons in chiral theory. Abstract The many particle decays ρ(770) → 4π and ω(782) → 5π are considered in detail in the approach based on the Weinberg Lagrangian or, in a new language, the Lagrangian of hidden local symmetry added with the term induced by the anomalous Lagrangian of Wess and Zumino.

Objective: To use cluster analysis to identify psychological profiles and related mental health symptoms among male and female juvenile offenders. Method: Juvenile offenders (N = 141) incarcerated in the California Youth Authority completed the Minnesota Multiphasic Personality Inventory (MMPI) and the Massachusetts Youth Screening Instrument-Version 2 (MAYSI-2). Results: MMPI cluster analysis ...

Cystic fibrosis (CF) is a lethal recessive genetic disease caused primarily by the F508del mutation in the CF transmembrane conductance regulator (CFTR). The potentiator VX-770 was the first CFTR modulator approved by the FDA for treatment of CF patients with the gating mutation G551D. Orkambi is a drug containing VX-770 and corrector VX809 and is approved for treatment of CF patients homozygou...

†Department of Advanced Materials, Institute of Technology and Science, The University of Tokushima, 2-1 Minamijosanjima, Tokushima 770-8506, Japan ‡Department of Life System, Institute of Technology of Science, The University of Tokushima, 2-1 Minamijosanjima, Tokushima 770-8506, Japan §National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan ¶Department of Materi...

We purified a 29-kDa Helicobacter pylori outer membrane protein (Omp29 protein) and cloned the gene encoding the protein from H. pylori strain ATCC 43504. The Omp29 gene corresponded to the reported JHP73 and the HP78-79 genes of H. pylori strains. A corresponding nucleotide fragment was detected in all 150 tested H. pylori clinical isolates by PCR or Southern blotting. The amplified Omp29-corr...

We study the contributions of kaon pair originating from resonance $\ensuremath{\rho}(770)$ for three-body decays $B\ensuremath{\rightarrow}DK\overline{K}$ by employing perturbative QCD approach. According to predictions in this work, intermediate state $\ensuremath{\rho}(770{)}^{0}$ are relatively small such as ${B}^{0}\ensuremath{\rightarrow}{\overline{D}}^{0}{K}^{+}{K}^{\ensuremath{-}}$, ${B...

W1282X is a common nonsense mutation among cystic fibrosis patients that results in the production of a truncated Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) channel. Here we show that the channel activity of the W1282X-CFTR polypeptide is exceptionally low in excised membrane patches at normally saturating doses of ATP and PKA (single channel open probability (PO) < 0.01). Howev...

Cyanobacteria are able to produce a wide range of secondary metabolites, including toxins and protease inhibitors, with diverse biological activities. Microginins are small linear peptides biosynthesized by cyanobacteria species that act against proteases. The aim of this study was to isolate and identify microginins produced by the LTPNA08 strain of Microcystis aeruginosa, as well as to verify...

The most common mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leads to deletion of the phenylalanine at position 508 (ΔF508) in the CFTR protein and causes multiple folding and functional defects. Contrary to large-scale efforts by industry and academia, no significant therapeutic benefit has been achieved with a single "corrector". Therefore, investigations co...