نتایج جستجو برای: تمرینات تعلیقی trx

تعداد نتایج: 6683  

2012
Tao Luo Tingting Fan Yinan Liu Maxi Rothbart Jing Yu Shuaixiang Zhou Bernhard Grimm Meizhong Luo

The chloroplast thioredoxins (TRXs) function as messengers of redox signals from ferredoxin to target enzymes. In this work, we studied the regulatory impact of pea (Pisum sativum) TRX-F on the magnesium (Mg) chelatase CHLI subunit and the enzymatic activation of Mg chelatase in vitro and in vivo. In vitro, reduced TRX-F activated the ATPase activity of pea CHLI and enhanced the activity of Mg ...

2017
Zhi-xiang Yuan Lu Jia Lee Yong Lim Ju-chun Lin Gang Shu Ling Zhao Gang Ye Xiao-xia Liang Hongming Ji Hua-lin Fu

Previously, 3,5-dipentadecyloxybenzamidine hydrochloride (TRX-20)-modified liposomes were reported to specifically target mesangial cells (MCs) in glomeruli. To further gain a better understanding of the characteristics and potential application for glomerular diseases of TRX-20-modified liposomes, we synthesized TRX-20 and prepared TRX-20-modified liposomes (TRX-LPs) with different molar ratio...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2005
Rees L Lee Raymond C Rancourt Greg del Val Kami Pack Churee Pardee Frank J Accurso Carl W White

Excessive neutrophil elastase activity within airways of cystic fibrosis (CF) patients results in progressive lung damage. Disruption of disulfide bonds on elastase by reducing agents may modify its enzymatic activity. Three naturally occurring dithiol reducing systems were examined for their effects on elastase activity: 1) Escherichia coli thioredoxin (Trx) system, 2) recombinant human thiore...

Journal: :Genetics 1999
T R Breen

trithorax (trx) encodes chromosome-binding proteins required throughout embryogenesis and imaginal development for tissue- and cell-specific levels of transcription of many genes including homeotic genes of the ANT-C and BX-C. trx encodes two protein isoforms that contain conserved motifs including a C-terminal SET domain, central PHD fingers, an N-terminal DNA-binding homology, and two short m...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
S Kakolyris A Giatromanolaki M Koukourakis G Powis J Souglakos E Sivridis V Georgoulias K C Gatter A L Harris

PURPOSE Thioredoxin (TRX), a low molecular weight protein, exerts reduction-oxidation control over a number of transcription factors involved in cell activation and proliferation. High TRX mRNA levels have been found in lung carcinomas, a trait associated with a growth and survival advantage. EXPERIMENTAL DESIGN In this study, we examined the immunohistochemical expression of human TRX in nor...

2014
Min Hee Lee Hyun Mi Jeon Ji Hye Han Nayoung Park Chulhun Kang Jonathan L. Sessler Jong Seung Kim

Thioredoxin (Trx) is a redox-active protein that plays a key role in mitigating the effects of oxidative stress. The secretion of Trx on the plasma membrane has been suggested as a distinctive feature of inflammation. However, selective monitoring of membrane-associated Trx activity has proved challenging because of the ubiquity of Trx action in cells. Here, we report a Trx-specific probe that ...

Journal: :International journal of molecular medicine 2006
Kenichi Hamano Yasushi Seo Hirotaka Kato Miyuki Kato Yoshihiko Yano Toshiaki Ninomiya Masato Kasuga

Oxidative stress contributes to the pathogenesis of various hepatic injuries. Thioredoxin (TRX) is an indicator of oxidative stress, reported to be increased in the serum of patients with chronic hepatitis C with the progression of fibrosis. The aim of this study was to evaluate the clinical significance of the expression of TRX and thioredoxin-binding protein-2 (TBP-2), which is a negative reg...

2010
Youn-Shen Bee Shwu-Jiuan Sheu Yi-Ling Ma Hsiu-Chen Lin Wen-Tsang Weng Hsiao-Mei Kuo Huei-Chun Hsu Chia-Hua Tang Jau-Cheng Liou Ming-Hong Tai

PURPOSE Vasostatin 48 (VS48) is a peptide of 48 amino acids derived from calreticulin. This study aimed to investigate the effects of topical application of VS48 eyedrops on experimental choroidal neovascularization (CNV). METHODS Recombinant VS48 was expressed and purified as a thioredoxin (TRX)-fused protein, TRX-VS48. The anti-angiogenic effects of TRX-VS48 were validated by migration and ...

Journal: :Cancer research 2004
Nichole Boyer Arnold Knut Ketterer Jörg Kleeff Helmut Friess Markus W Büchler Murray Korc

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive human malignancy in which Smad7 is commonly overexpressed. Analysis by differential display identified thioredoxin-1 (TRX) as a gene whose basal expression is increased in COLO-357 pancreatic cancer cells engineered to overexpress Smad7. To delineate the biological consequences of TRX overexpression, we assessed TRX mRNA levels in PDAC an...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2004
Raymond C Rancourt Shusheng Tai Malcolm King Sonya L Heltshe Churee Penvari Frank J Accurso Carl W White

The persistent and viscous nature of airway secretions in cystic fibrosis (CF) disease leads to airway obstruction, opportunistic infection, and deterioration of lung function. Thioredoxin (Trx) is a protein disulfide reductase that catalyzes numerous thiol-dependent cellular reductive processes. To determine whether Trx can alter the rheological properties of mucus, sputum obtained from CF pat...

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