Drugs with clinical adverse effects are compared in an ex vivo 3-dimensional multi-cellular human liver slice model. Functional markers of oxidative stress and mitochondrial function, glutathione GSH and ATP levels, were affected by acetaminophen (APAP, 1 mM), diclofenac (DCF, 1 mM) and etomoxir (ETM, 100 μM). Drugs targeting mitochondria more than GSH were dantrolene (DTL, 10 μM) and cyclospor...

Applications based on overlays have become very popular, due to the separation they provide and the improvement of perceived QoS by the end-user. Recent studies show that overlays have a significant impact on the traffic management and the expenditures of the underlying network operators. In this paper, we define a framework for Economic Traffic Management (ETM) mechanisms that optimize the tra...

This paper presents a comparison of Earth Observing 1 (EO-1) Advanced Land Imager (ALI) and Landsat-7 Enhanced Thematic Mapper Plus (ETM+) images collected over an agricultural region in northwest Mexico. Across 115 fields with a range of cover types, radiance measurements collected by ALI were within 3% of ETM+ for all five common bands. Crop discrimination was significantly improved with ALI ...

MicroRNAs (miRNA) are small endogenous RNA molecules, which regulate target gene expression at post-transcriptional level. Besides, miRNA activity can be controlled by a newly discovered regulatory mechanism called endogenous target mimicry (eTM). In target mimicry, eTMs bind to the corresponding miRNAs to block the binding of specific transcript leading to increase mRNA expression. Thus, miRNA...

The aim of this paper is to investigate the feasibility of using Landsat ETM+ data for the determination of leaf area index (LAI). The investigation is prompted by the need for obtaining spatially distributed data on LAI to be used as input for carbon modelling of northern boreal forests. Detailed field data have been collected in a coniferous forest area in Uppland, central Sweden, dominated b...

Many land-management agencies are caught between decreased budgets and increasing public interest. Furthermore, semi-arid landscapes are sensitive to management prescriptions and use, and require a significant amount of monitoring in order to assess vegetation productivity and health. The purpose of this study was to evaluate the use of Landsat Enhanced Thematic Mapper (ETM) Imagery to monitor ...

Comparing satellite data derived map products are affected by differences in data characteristics, image acquisition dates, processing techniques, and classification schemes used for assigning pixels to a thematic class. By comparing two forest maps generated from Landsat Enhanced Thematic Mapper Plus (ETM+) and Advanced Very High Resolution Radiometer (AVHRR) images acquired on the same day, a...

The National Aeronautics and Space Administration (NASA) Landsat program has been dedicated to sustaining data continuity over the 20-year period during which Landsat Thematic Mapper (TM) and Enhanced TM Plus (ETM+) sensors have been acquiring images of the earth's surface. In 2000, NASA launched the Earth Observing-1 (EO-1) Advanced Land Imager (ALI) to test new technology that could improve t...

In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H-Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently in use for the treatment of the AD. Molecular fragments being specific for active and inactive com...