نتایج جستجو برای: تشخیص تقلب کمیسازی mtdna 12s rrna real
تعداد نتایج: 609955 فیلتر نتایج به سال:
Mutations in mitochondrial genome have been found to be associated with hearing loss. Of these, the mitochondrial 12S rRNA and tRNASer(UCN) are the hot spots for pathogenic mutations associated with deafness. To understand the putative role of mitochondrial DNA (mtDNA) mutations in hearing loss, we recently initiated a mutational screening for the mtDNA mutations in Hangzhou area from Zhejiang ...
Mitochondrial DNA (mtDNA) sequence variation was examined in eight taxa of the African rodent family Bathyergidae, as well as in two taxa representative of the Old-World hystricognathid rodent families Petromyidae and Thryonomyidae. A total of 812 bp, constituting domains I-III of the 12S ribosomal rRNA gene, were compared for each taxon. The high levels of intrafamilial mtDNA sequence divergen...
در این مطالعه از pcr معمولی و real time pcr با استفاده از ژن میتوکندریایی s rrna 12 مرغ برای جداسازی و تعیین مقدار خمیر مرغ در نمونه های غذایی استفاده گردید. نمونه ها شامل غلظت های مختلف dna مرغ، نمونه های تجاری سوسیس و همبرگر و نمونه های تجربی شامل غلظت های مختلف خمیر مرغ که تحت دماهای مختلف حرارت داده شدند، بودند. نتایج نشان داد که pcr با پرایمر اختصاصی گونه می تواند تا غلظت 01/0 نانوگرم dna ...
Mitochondria are one of the enzymatic sources of reactive oxygen species (ROS) and could also be a major target for ROS-mediated damage. We hypothesized that ROS may induce mitochondrial DNA (mtDNA) damage, which leads to defects of mtDNA-encoded gene expression and respiratory chain complex enzymes and thus may contribute to the progression of left ventricular (LV) remodeling and failure after...
While circulating tumor-derived molecules have been identified in a variety of malignant tumors, it is sometimes difficult to detect the molecular targets due to the lower serum concentration. We report that evaluation of circulating tumor-derived mitochondrial DNA (mtDNA) seems to have novel efficiency for detecting tumoral micrometastasis. In murine xenografting human oral cancer cells, human...
Irreversible hearing loss is a catastrophic complication of treatment with aminoglycoside antibiotics such as streptomycin, gentamycin, and kanamycin. Many kindreds showing a matrilineal pattern of inheritance of this trait have been described in China where the widespread use of aminoglycoside antibiotics accounts for approximately 25% of profound deafness in some districts. Because of the cha...
Objective: The objective of this study is to examine loci’s mutation frequencies for the four widespread deafness-associated genes in Han Chinese with hearing loss in the southern Fujian region and to establish the correlation between hearing loss levels and nucleotide modifications. Methods: Microarray-based mutation was detected nine hot spot mutations of the most prevalent deafness-related g...
To investigate the potential role of somatic mitochondrial DNA (mtDNA) mutations in tumorigenesis, the occurrence of mutations in mtDNA of ovarian carcinomas was studied. We sequenced the D-loop region of mtDNA of 15 primary ovarian carcinomas and their matched normal controls. Somatic mtDNA mutations were detected in 20% (3 of 15) tumor samples carrying single or multiple changes. Complete seq...
To investigate the potential role of somatic mitochondrial DNA (mtDNA) mutations in tumorigenesis, the occurrence of mutations in mtDNA of ovarian carcinomas was studied. We sequenced the D-loop region of mtDNA of 15 primary ovarian carcinomas and their matched normal controls. Somatic mtDNA mutations were detected in 20% (3 of 15) tumor samples carrying single or multiple changes. Complete seq...
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