The coordination of cell polarity within the plane of the tissue layer (planar polarity) is crucial for the development of diverse multicellular organisms. Small Rac/Rho-family GTPases and the actin cytoskeleton contribute to planar polarity formation at sites of polarity establishment in animals and plants. Yet, upstream pathways coordinating planar polarity differ strikingly between kingdoms....

Chronic inflammation is a molecular element of the metabolic syndrome and type 2 diabetes. Saturated fatty acids (SFAs) are considered to be an important proinflammatory factor. However, it is still incompletely understood how SFAs induce proinflammatory cytokine expression. Hereby we report that activating transcription factor (ATF) 4, a transcription factor that is induced downstream of metab...

We identified the enzyme(s) involved in the hydrolysis of the ethyl ester prodrug CDP323 (C28H29BrN403) and characterized its transesterification in the presence of ethanol with special emphasis on the risks of drug-drug interaction. The hydrolysis of CDP323 was evaluated in vitro using human liver and intestinal microsomes and recombinant human carboxylesterases (hCES1 and 2) and was shown to ...

No hay resúmenes disponibles. Realidad: Revista de Ciencias Sociales y Humanidades No. 161, 2023: 5.

1Department of Biology and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China 2College of Chinese Medicine Materials, Jilin Agricultural University, Changchun 130118, China 3Eco-friendly New Materials Research Group, Korea Research Institute of Chemical Technology, Daejeon 305-343, Korea 4Korean Lichen Research Institute, Sunchon National University, Sun...