conclusions: the results of the present study indicated that oral preparation of cm with an acceptable taste is feasible. background: chlorpheniramine maleate (cm) is widely used as an antihistaminic drug but it is very bitter and as yet no mouth dissolving/disintegrating taste-masked preparation that might be useful for pediatric and geriatric patients is available in the market. objectives: t...

Introduction: Since organophosphorus compounds (OP) are toxic and designed to destroy insects and pest species, there are many hazards associated with their use. Although, the main target site of these compounds is acetylcholinesterase (AChE), however it has become increasingly evident that OPs have also other direct effects on cellular processes. In the present study, the effects of low con...

Mechanosensory transduction (MST) in proprioceptors, and other low threshold mechanosensory nerve terminals (LTMT), has been debated intensely for decades. MST muscle spindles produces a receptor potential that encodes stimulus speed duration, is predominantly due to Na+, little Ca2+, plus some transient, non-mechanically-gated K+ ion fluxes. The abundant, multiple Na+-selective DEG/ENaC channe...

The results of experimental studies on the phase formation CaAl2O4 (CA) and CaAl4O7 (CA2) from CaCO3-Al2O3 powder mixtures in temperature range 1250 - 1450 ° C ate presented. In order to calculate content raw materials charge, criterion obtaining high-alumina clinker with Al2O3 71 72 wt. % CaO 27 28 wt.% is proceeded. This mass ratio system state diagram suggests presence two calcium-aluminate ...

ion channels are responsible for control of cell function in excitable tissues such as heart and brain and also in organs and tissues traditionally thought to be non- excitable including liver and epithelium. in the present research, the effect of lead (pb2+) on ca2+ -dependent action potential and currents was studied in f77 neuronal soma membrane of helix aspersa. for this purpose, action pot...

the complexation reactions between mg2+, ca2+, sr2+ and ba2+ metal cations with 15-crown-5 (15c5) were studied in acetonitrile (an)-methanol (meoh) binary mixtures at different temperatures using conductometric method. 15c54 forms 1:1 complexes with mg2+, ca2+ and sr2+ cations in solutions. the ma2+ cation forms a 2:1 complex (ratio of lighand to cation) in solutions. a linear relation was obse...

Abstract Introduction Calmodulin (CaM) is a highly conserved mediator of calcium (Ca2+) dependent signalling. Its flexible structure allows CaM to bind and modulate many targets, including cardiac ion channels. Genotyping has revealed several mutations associated with congenital disorders heart rhythm, known as long QT-syndrome (LQTS). LQTS patients suffer from prolonged ventricular recovery ti...

TOPIC: Lung Cancer TYPE: Original Investigations PURPOSE: Non-small cell lung cancer (NSCLC), one of the leading causes cancer-related death, has a low 5-year survival rate owing to inevitable acquired resistance toward antitumor drugs, platinum-based chemotherapy, and targeted therapy. Epidermal growth factor (EGF)-EGF receptor (EGFR) signaling activates downstream events phospholipase C/inosi...

We developed a method to evaluate the activity of Na+–Ca2+ exchanger (NCX) and sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) with fluorescence microscopy in mouse ventricular cardiomyocytes. In non-beating cardiomyocytes, α-adrenoceptor stimulation by phenylephrine caused decrease cytoplasmic Ca2+ concentration, which was inhibited SEA0400, an NCX inhibitor, but not cyclopiazonic acid, SERCA ...