In the title compound, 5-(4-chloro-phen-yl)-1-(4-methoxy-phen-yl)-3-(trifluoro-meth-yl)-1H-pyrazole (SC-560), C(17)H(12)ClF(3)N(2)O, a COX-1-selective inhibitor, the dihedral angles between the heterocycle and the chlorobenzene and methoxybenzene rings are 41.66 (6) and 43.08 (7)°, respectively. The dihedral angle between the two phenyl rings is 59.94 (6)°. No classic hydrogen bonds are possibl...

Manish Naja*, Piyush Bhardwaj, Narendra Singh, Phani Kumar, Rajesh Kumar, N. Ojha, Ram Sagar, S. K. Satheesh, K. Krishna Moorthy and V. R. Kotamarthi Aryabhatta Research Institute of Observational Sciences, Nainital 263 002, India National Center for Atmospheric Research, Boulder, Colorado, USA Indian Institute of Astrophysics, Bengaluru 560 034, India Centre for Atmospheric and Oceanic Science...

The present study aimed to investigate the combined effects of Taxol and cyclooxygenase (COX) inhibitors on angiogenesis and cell apoptosis of SKOV-3 human ovarian carcinoma cell xenograft-bearing mice. The experiments were continued for 28 days. Animals were treated with 3 mg/kg SC-560 (a COX-1-selective inhibitor) alone, 100 mg/kg celecoxib (a COX-2-selective inhibitor) alone or SC-560/celeco...

Norio Kikuchi, Allen Ehrlicher, Daniel Koch, Josef A. Käs, Sriram Ramaswamy and Madan Rao Centre for Condensed Matter Theory, Department of Physics, Indian Institute of Science, Bangalore 560 012, India Translational Medicine, Brigham and Women’s Hospital, Harvard Medical School, One Blackfan Circle, Karp 6, Boston, MA 02115, USA Institute of Soft Matter Physics, Universität Leipzig, Linnéstraß...

This study was designed to evaluate the effect of cyclooxygenase-1 (COX-1) inhibitor, SC-560, combined with cisplatin or taxol, on angiogenesis in human ovarian cancer xenografts. Mice were treated with intraperitoneal (i.p.) injections of SC-560 6 mg/kg/day, i.p. injections of cisplatin 3 mg/kg every other day and i.p. injections of taxol 20 mg/kg once a week for 21 days. Vascular endothelial ...

Photoluminescence spectra of tailored Ga~A1!P/GaP quantum well heterostructures exhibit strong short-wavelength peaks at 363, 560, and 6002700 nm. The peak at 560 nm seems to originate from a no-phonon transition. All the transitions are observed up to 200 K. Light emitting diodes made with the same heterostructure predominently emit 560 nm light ~green! with a background of 700 nm ~red! at roo...

a Faculty of Economics, Osaka University, 1-7, Machikaneyama, Toyonaka, Osaka 560, Japan E-mail: [email protected] b Department of Infomatics and Mathematical Science, Graduate School of Engineering Science, Osaka University, 1-3, Machikaneyama, Toyonaka, Osaka 560-8531, Japan E-mail: [email protected] c Department of Infomatics and Mathematical Science, Graduate School of E...

R.Bhattacharya, Subbarao Kanchi, 2 C. Roobala, A. Lakshminarayanan, Oliver H. Seeck, Prabal K. Maiti, K.G.Ayappa, N. Jayaraman, and J. K. Basu Department of Physics, Indian Institute of Science, Bangalore, 560 012, India. Department of Chemical Engineering, Indian Institute of Science, Bangalore, 560 012, India. Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560 012, I...