Overcoming resistance to chemotherapy is an arduous challenge in the treatment of colorectal cancer (CRC), particularly since the underlying molecular mechanisms remain obscure. In the present study, we reported that miR‑874-3p was markedly downregulated in CRC tissues compared with that in adjacent normal colorectal epithelial tissues. Upregulation of miR-874-3p attenuated the chemoresistance ...

PIN1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that regulates multiple signaling pathways to control cell fate and is found to be over-expressed in cancers, including hepatocellular carcinoma (HCC). However, the regulation of PIN1 in HCC remains poorly defined. Micro-RNAs (miRNAs) have been reported to play a pivotal role in oncogenesis by targeting the 3'-untranslated region (UTR) of m...

Interferon-γ (Interferon gamma, IFNG) is an important cytokine involved in providing resistance to mycobacterial diseases. Common variants of IFNG, such as IFNG +874 T/A(rs2430561), may be related to tuberculosis susceptibility, but this association has not been consistently observed. We performed an updated meta-analysis to evaluate the association between the IFNG +874 T/A (rs2430561) polymor...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 185 No. 5 859–874 www.jcb.org/cgi/doi/10.1083/jcb.200812167 JCB 859 Correspondence to Anna Santamaria: [email protected] A. Uldschmid’s present address is Viramed Biotech AG, Behingerstrasse 11, D-82152, Planegg, Germany. Abbreviations used in this paper: DHC, dynein heavy chain; DIC, dynein intermediate chain; GL2, Photinus pyr...

871 The Rockefeller University Press $30.00 J. Cell Biol. Vol. 216 No. 4 871–873 https://doi.org/10.1083/jcb.201702028 When leucocytes encounter ligand-bearing targets, tens to hundreds of receptors of different types are triggered, leading to downstream signaling. How receptor triggering occurs is uncertain (van der Merwe and Dushek, 2011), and even less is known about how the distinct signals...

the successfully breeding of the hybrids 873?874 had settled the problem that the yield was not uniform to the silk quality in silkworm varieties. in this paper, we illuminated the key technology, principle, hints and methods for selection in breeding spring-and-autumn rearing silkworm varieties were analyzed using the procedure of breeding the hybrid of 873?874 as example.

To explore the association of TNF-α-308 and IFNγ +874 genetic polymorphisms with type 2 diabetes mellitus (DM) in Egyptian cases. Participants included 207 cases with type 2 DM, 93 males and 114 females. Their mean age was 57 years. They were compared to a control group of 212 healthy unrelated subjects from the same locality. DNA was amplified using PCR with sequence specific primers for detec...