The cleavage of the autotransporter adhesin involved in diffuse adherence (AIDA-I) of Escherichia coli yields a membrane-embedded fragment, AIDAc, and an extracellular fragment, the mature AIDA-I adhesin. The latter remains noncovalently associated with AIDAc but can be released by heat treatment. In this study we determined the mechanism of AIDA-I cleavage. We showed that AIDA-I processing is ...

In this paper, we propose a superior technique for distributed time-critical communication using AIDA (Adaptive Information Dispersal Algorithm), a novel elaboration on Michael O. Rabin's IDA [Rabi89]. We show that using a small dynamically-controlled amount of redundancy, stringent timing constraints imposed on periodic as well as sporadic communication requests in a distributed realtime syste...

Adaptive Incremental Dynamic Analysis (AIDA) is a novel ground motion selection scheme that adaptively changes the ground motion suites at different ground motion intensity levels to match hazardconsistent properties for structural response assessment. Incremental Dynamic Analysis (IDA), a current dynamic response history analysis practice in Performance-Based Earthquake Engineering (PBEE), use...

We propose a new transport protocol, TCP Boston, that turns ATM's 53-byte cell-oriented switching architecture into an advantage for TCP/IP. At the core of TCP Boston is the Adaptive Information Dispersal Algorithm (AIDA), an efficient encoding technique that allows for dynamic redundancy control. AIDA makes TCP/IP's performance less sensitive to cell losses, thus ensuring a graceful degradatio...

The purpose of this paper is to report an audit of 2437 downloads of the AIDA interactive educational diabetes simulator. AIDA is a diabetes computer program that permits the interactive simulation of plasma insulin and blood glucose profiles for educational, demonstration, and self-learning purposes. It has been made freely available, without charge, on the Internet as a noncommercial contribu...

In 1996, an interactive educational diabetes simulator called AIDA was released without charge on the Internet as a noncommercial contribution to continuing diabetes education. Over the past 5 years, over 100,000 people have visited the AIDA Web pages at http://www.2aida.org and over 25,000 copies of the program have been downloaded free-of-charge. Previous Diabetes Information Technology & Web...

In this paper, we propose a superior technique for distributed time-critical communication using AIDA, a novel elaboration on Michael O. Rabin's IDA 19]. We show that using a small dynamically-controlled amount of redundancy, stringent timing constraints imposed on periodic as well as sporadic communication requests in a distributed real-time system can be fulllled up to any degree of conndence...

Autotransporters deliver virulence factors to the bacterial surface by translocating an effector passenger domain through a membrane-anchored barrel structure. Although passenger domains are diverse, those found in enteric bacteria autotransporters, including AIDA-I in diffusely adhering Escherichia coli (DAEC) and TibA in enterotoxigenic E. coli, are commonly glycosylated. We show that AIDA-I ...

The current model for autodisplay suggests a mechanism that allows a passenger protein to be translocated across the outer membrane by coordinate action of a C-terminal beta-barrel and its preceding linking region. The passenger protein, linker, and beta-barrel are together termed the autotransporter, while the linker and beta-barrel are here referred to as the translocation unit (TU). We chara...