Multidrug-resistant Acinetobacter baumannii is one of the most important pathogens in intensive care units related to morbidity and mortality. Colistin is being used increasingly as “salvage” therapy for these patients. However, resistance to colistin in A. baumannii has recently been reported. We herein present a case in which ventilator-associated pneumonia due to A. baumannii developed in on...

The resurgence of Chikungunya virus (CHIKV) in the southern, northeastern and northern parts of Thailand, inflicting approximately 46,000 reported cases since October 2008 until December 2009, has raised public health concerns. In the present study, we characterized nearly complete genome sequences of four CHIKV isolates obtained from 2008 to 2009 outbreaks in Thailand. Phylogenetic analysis wa...

Alcohol addiction is a social problem and a relatively common disease of western countries like Europe and the USA. From 20 to 40 % of subjects admitted to hospitals have alcohol-related problems1 and in elderly people alcohol-related disorders represent as frequent a reason for hospitalization as myocardial infarction2. Among the diseases related to alcoholism, nutritional disorders remain one...

Carbohydrate-rich foods are an essential component of the diet, providing the glucose that is continuously required by the nervous system and some other cells and tissues in the body for normal function. There is some concern that too much carbohydrate or certain types of carbohydrate such as fructose or the high glycaemic index carbohydrate foods that produce large, rapid increases in blood gl...

This paper reviews the literature on interindividual variability in human sleep parameters, sleepiness, responses to sleep deprivation, and manifestations of sleep disorders. Variability among individuals in sleep/wake biology and behavior is pervasive. The magnitude of such individual differences is often considerable and comparable to the effect sizes of many experimental and clinical interve...

Although the abundant sterile alpha motif (SAM) domain was originally classified as a protein-protein interaction domain, it has recently been shown that certain SAM domains have the ability to bind RNA, defining a new type of post-transcriptional gene regulator. To further understand the function of SAM-RNA recognition, we determined the solution structures of the SAM domain of the Saccharomyc...

ING1 gene, the founding member of the ING tumor suppressor family, was originally identified through subtractive hybridization between normal mammary epithelial cells and breast cancer cell lines, and subsequent in vivo selection of genetic suppressor element that displayed oncogenic features. The four additional members of the ING family (ING2-5) were recently identified and all the gene produ...