In high-dimensional data domains, the performance of conventional tree-based access structures is occasionally outperformed by simple sequential scans. To this end, the introduction of approximation-based methods helped speed-up queries by providing compact representations of stored data. Approximation methods exploit vector quantization to index data mainly presumed to follow a uniform distrib...

Interactions within proteins of the Bcl-2 family are key in the regulation of apoptosis. The death-inducing members control apoptotic mechanisms partly by antagonizing the prosurvival proteins through heterodimer formation. Structural and biophysical studies on these complexes are providing important clues to understand their function. To help improve our knowledge on protein-protein interactio...

RÉSUMÉ. Les Agents Conversationnels Assistants sont une sous-classe des Agents Conversationnels Animés, dédiée à la Fonction d’Assistance pour les applications et services du grand public. Les nouvelles applications Internet sont un domaine particulièrement intéressant pour étudier les agents assistants pour le grand public. Nous avons donc développé un logiciel orienté Web, appelé le « toolkit...

The DIVA (Data IntensiVe Architecture) system incorporates Processing-In-Memory (PIM) chips as smart-memory coprocessors to a microprocessor, with a separate memory-to-memory interconnect, thus exploiting the inherent memory bandwidth both on chip and across the system. DIVA targets several classes of bandwidth-limited applications, including multimedia applications and pointer-based and sparse...

DiVA – Digitala vetenskapliga arkivet (DiVA Archive) – is a comprehensive description of a searchable archive containing the documents, which are published in an electronic format at Uppsala University in Sweden. The DiVA System, developed by the Electronic Publishing Centre at Uppsala University Library, makes it possible to reuse and enhance data originally entered by the author as the basis ...

APXIVA is an RTX toxin of Actinobacillus pleuropneumoniae that is a candidate antigen to differentiate infected from vaccinated animals (DIVA). Insertion of ISApl1 into the apxIVA gene is known to compromise an APXIVA-based DIVA approach, as is potentially a TGG to TGA mutation in the apxIVA gene. ISApl1 was found in 63/349 (18.1%) A. pleuropneumoniae isolates from England and Wales including s...

The tuberculin skin test has been used for the diagnosis of bovine and human tuberculosis (TB) for over a hundred years. However, the specificity of the test is compromised by vaccination with the Mycobacterium bovis-derived vaccine strain bacille Calmette-Guérin (BCG). Since current promising vaccines against bovine TB are based on heterologous prime-boost combinations that include BCG, there ...