We developed an adenoviral vector, in which Yamanaka’s four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for a transient period of time, synchronizing the reprogramming process with the majority of transduced cells assuming induced pluripotent stem ce...

Fast-twitch skeletal muscles are specialized for in vivo motor functions that require high power (mastication and load lifting), high speed (eyelid blink), or a combination of the two (withdrawal reflexes and escape responses). Those functions that rely on high power often involve tetanic stimulation of the effector muscles, resulting in sustained force generation even during tetani that are no...

We report a phase diagram mapping for solid hydrogen based on several thousands of Raman spectroscopic data points obtained at simultaneous high-pressure and -temperature (PT) experiments. Information about behavior in the range 300 K up to melting line 0--300 GPa has remained almost unknown date; therefore, revealing it is very desirable. A network analysis isothermal isobaric dependencies var...

(11:21); hence from the very nature of creation Browne may conclude: "All things began in order, so shall they end, and so shall they begin again; according to the ordainer of order and mystical mathematics of the City of Heaven." Browne could not know in 1658 that he would live for another 24 years. As though The Garden of Cyrus is actually his final work he joins it, like a snake swallowing i...

We have seen that the BH procedure controls the FDR for multiple testing when the p-values are independent. How can we control the FDR under dependence? Here, we consider the case where the statistics have distribution Y ∼ N (μ,Σ); in the past, we have assumed that Σ = Ip. If the covariance matrix Σ were known, we could reduce to the independent case using the transformation Y ′ = Σ− 1 2Y , so ...