The low distribution of hydrophobic anticancer drugs in patients is one the biggest limitations during conventional chemotherapy. SDS-based polyelectrolyte multicore nanocarriers (NCs) prepared according to layer by (LbL) procedure can release paclitaxel (PTX), and selectively kill cancer cells. Our main objective was verify antitumor properties PTX-loaded NCs examine whether drug encapsulated ...

Two new Drug Delivery Systems (DDS) cyclo[DKP-isoDGR]-PEG-4-Val-Ala-PTX (2) and cyclo[DKP-isoDGR]-PEG-4-sC18-Val-Ala-PTX (3), containing the cyclo[DKP-isoDGR] integrin ligand cytotoxic agent Paclitaxel (PTX), were synthesized to investigate influence of a PEG-4 chain sC18 cell-penetrating peptide (CPP) on cellular uptake cytotoxicity constructs. A “double click-reaction strategy” was planned, r...

Abstract Background Paclitaxel (PTX) has been suggested to be a promising front-line drug for gastric cancer (GC), while P-glycoprotein (P-gp) could lead resistance by pumping PTX out of GC cells. Consequently, it might hopeful way combat inhibiting the out-pumping function P-gp. Results In this study, we developed delivery system incorporating onto polyethylene glycol (PEG)-modified and oxidiz...

Paclitaxel (PTX)-coated devices decrease restenosis after femoropopliteal artery intervention. Recently, they have been linked to a potential increase in late mortality and amputation based on data of patients predominantly presenting with claudication. Outcome PTX chronic limb-threatening ischemia (CLTI) are unknown. The objective this study was compare outcome CLTI treated without PTX. Patien...

Purpose Polymeric micelles are attractive nanocarriers for tumor-targeted delivery of paclitaxel (PTX). High antitumor efficacy and low toxicity require that PTX mainly accumulated in tumors with little drug exposure to normal tissues. However, many PTX-loaded micelle formulations suffer from low stability, fast drug release, and lack of tumor-targeting capability in the circulation. To overcom...

PURPOSE Lipid nanoemulsions (LDEs) that bind to low-density lipoprotein (LDL) receptors used as carriers of paclitaxel (PTX) can decrease toxicity and increase PTX antitumoral action. The administration of simvastatin (Simva), which lowers LDL-cholesterol, was tested as an adjuvant to commercial PTX and to PTX associated with LDE (LDE-PTX). MATERIALS AND METHODS B16F10 melanoma-bearing mice w...

background: reviewing the literature reveals that pentoxifylline (ptx) plus tocopherol (vitamin e) are used mainly to promote sperm quality. however trials focusing on the effects of these drugs in female partner are limited. combination of pentoxifylline and vitamin e appeared to improve the pregnancy rate in patients with a thin endometrium by increasing the endometrial thickness and improvin...