BACKGROUND Whether knowledge of genetic risk for coronary heart disease (CHD) affects health-related outcomes is unknown. We investigated whether incorporating a genetic risk score (GRS) in CHD risk estimates lowers low-density lipoprotein cholesterol (LDL-C) levels. METHODS AND RESULTS Participants (n=203, 45-65 years of age, at intermediate risk for CHD, and not on statins) were randomly as...

OBJECTIVE We evaluated the clinical usefulness of a genetic risk score (GRS) based on 14 well-established variants for type 2 diabetes. RESEARCH DESIGN AND METHODS We analyzed 14 SNPs at HHEX, CDKAL1, CDKN2B, SLC30A8, KCNJ11, IGF2BP2, PPARG, TCF7L2, FTO, KCNQ1, IRS-1, GCKR, UBE2E2, and C2CD4A/B in 1,487 Japanese individuals (724 patients with type 2 diabetes and 763 control subjects). A GRS w...

Primary open-angle glaucoma (POAG) is a leading cause of blindness worldwide. The genetics of POAG are complex, and population-specific effects have been reported. Although many polymorphisms associated with POAG risk have been reported, few studies have analyzed their additive effects. We investigated, in a southern European Mediterranean population, the association between relevant POAG polym...

Geosynthetic-reinforced soil (GRS) technology has been used worldwide since the 1970s. An extension to its development is application as a bridge abutment, which was initially developed by Federal Highway Administration (FHWA) in United States, called GRS—integrated system (GRS-IBS). Now, there are several variations of this technology, includes GRS Integral Bridge (GRS-IB) Japan 2000s. In stud...

A generalized Ramanujan sum (GRS) is defined by replacing the usual Möbius function in the classical Ramanujan sum with the Souriau-Hsu-Möbius function. After collecting basic properties of a GRS, mostly containing existing ones, seven aspects of a GRS are studied. The first shows that the unique representation of even functions with respect to GRSs is possible. The second is a derivation of th...

We investigated the evolution of the response of human, chicken, alligator and frog glucocorticoid receptors (GRs) to dexamethasone, cortisol, cortisone, corticosterone, 11-deoxycorticosterone, 11-deoxycortisol and aldosterone. We find significant differences among these vertebrates in the transcriptional activation of their full length GRs by these steroids, indicating that there were changes ...

The design of a Geosynthetic Reinforced Soil (GRS) wall for internal stability requires computing the reinforcement embedment length against pullout failure. The location of failure plane is important input for this design. The current FHWA design guidelines assume the location of failure plane based on Rankine theory. While this assumption holds true for conventional walls it is unconservative...

PURPOSE We tested whether providing a genetic risk score (GRS) for coronary artery disease (CAD) would serve as a motivator to improve adherence to risk-reducing strategies. METHODS We randomized 94 participants with at least moderate risk of CAD to receive standard-of-care with (N = 49) or without (N = 45) their GRS at a subsequent 3-month follow-up visit. Our primary outcome was change in l...

We review state of the art of the gravitational reference sensor (GRS) for the Laser Interferometer Space Antenna (LISA). LISA consists of three identical spacecraft placed at the corners of an equilateral triangle with a 5 million kilometer baseline. In the LISA baseline design, the spacecraft at each corner will have two optical assemblies subtending an angle of 60 degrees. A proof mass (PM) ...