OBJECTIVE To investigate the health-related quality of life (HRQOL) and economic burden of patients with FM syndrome (FMS) and compare the changes in these parameters 3 months before and after FMS diagnosis. METHODS A total of 2098 patients with FMS (1818 previously diagnosed with FMS and 280 newly diagnosed with FMS) were enrolled in this study. The newly diagnosed patients with FMS particip...

BACKGROUND Fibromyalgia syndrome (FMS) is a long-term condition that affects between 1 and 5% of the general population and lies within the spectrum of medically unexplained symptoms (MUS). FMS can be difficult to diagnose and is usually done so as a diagnosis of exclusion. There is continuing debate regarding its legitimacy excluding other causes of symptoms. It is known that the diagnosis and...

................................................................................................................................ xv Introduction ............................................................................................................................. 1 Defining Terms Central to the Thesis .................................................................................. 3 Ch...

PURPOSE The correlation of fibromyalgia syndrome (FMS) with peptic ulcer disease (PUD) is unclear. We therefore conducted a cohort study to investigate whether FMS is correlated with an increased risk of PUD. METHODS In this study, we established an FMS cohort comprising 26068 patients aged more than 20 years who were diagnosed with FMS from 2000 to 2011. Furthermore, we established a control...

The HZ5-feline sarcoma virus (FeSV) is a new acute transforming feline retrovirus which was isolated from a multicentric fibrosarcoma of a domestic cat. The HZ5-FeSV transforms fibroblasts in vitro and is replication defective. A biologically active integrated HZ5-FeSV provirus was molecularly cloned from cellular DNA of HZ5-FeSV-infected FRE-3A rat cells. The HZ5-FeSV has oncogene homology wit...

Although intertester and intratester reliability have been common themes in Functional Movement Screen (FMS) research, the criterion validity of manual grading is yet to be comprehensively examined. This study compared the FMS scores assigned by a certified FMS tester to those measured by an objective inertial-based (IMU) motion capture system. Eleven female division I collegiate athletes perfo...

Rheumatological syndromes are generally chronic and this is often reflected in the onset and persistence of symptoms such as pain, whose physiopathological characteristics may change over time. It has been known for some time that as many as 15-30% of patients with classic autoimmune or rheumatic disorders also have a comorbid fibromyalgia syndrome (FMS). As these rates are much higher than the...

The colony-stimulating factor-1 (CSF-1) regulates survival, growth, and differentiation of monocytes by binding to a single class of high-affinity receptors. The CSF-1 receptor is identical to the product of the c-fms protooncogene. The present studies monitored the effects of TPA and CSF-1 on c-fms gene expression in human monocytes. The results demonstrate that TPA downmodulates the constitut...

Genetic and environmental factors may play a role in the etiopathology of fibromyalgia syndrome (FMS) and other related syndromes. There is a high aggregation of FMS in families of FMS patients. The mode of inheritance is unknown but it is most probably polygenic. There is evidence that polymorphisms of genes in the serotoninergic, dopaminergic and catecholaminergic systems play a role in the e...

BACKGROUND Albeit exercise is currently advocated as one of the most effective management strategies for fibromyalgia syndrome (FMS); the implementation of exercise as a FMS treatment in reality is significantly hampered by patients' poor compliance. The inference that pain catastrophizing is a key predictor of poor compliance in FMS patients, justifies considering the alteration of pain catast...