background and aims: epigallocatechin-3-gallate (egcg) is a polyphenolic compound from green tea, which its anticancer effects on many types of cancers have been confirmed, but the molecular mechanism by which egcg induces apoptosis remains unknown. the aim of the present study was to investigate anti-proliferative properties and apoptotic signaling pathway of egcg on pc3 human prostate cancer ...

introduction: recently, due to the special characteristics of 166ho and chitosan, 166ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. this complex has been lately prepared with high radiochemical purity in our lab. the preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and normal tissues before...

objective(s): neuroinflammation in parkinson disease (pd) is associated with glial cells activation and production of different inflammatory cytokines. in this study, we investigated the effect of chronic administration of 8-oh-dpat on 6-ohda-induced catalepsy and levels of inflammatory cytokines in cerebrospinal fluid (csf).   materials and methods: catalepsy was induced by unilateral infusion...

background: copper-64 (t1/2=12.7 h) is an important radionuclide used both in pet imaging and therapy. [64cu]-pyruvaldehyde-bis (n4-methylthiosemicarbazone) ([64cu]-ptsm) is one of the most famous copper radiopharmaceuticals with unique specifications (suitable half life, stability, etc.). the wide range of 64cu applications arouse great interest for its production. materials and methods: cu-64...

micrornas (mirnas) are a class of small non coding regulatory rnas that have key functions in multiple cell processes. deregulation of these tiny mirnas are involved in various human diseases. mir-155 is one of the multifunctional mirna that its over-expression has been found to be associated with different kinds of cancer such as leukemia, breast and colon cancers. it is thought that deregulat...

dactylogyrus spp. are monogenean worms found mostly as ectoparasites on the gills of several fish species, including carp and goldfish. these parasites are commonly detected by microscopic analysis of the gill lamellae, but this is time-consuming and technically difficult. in contrast to this conventional method, molecular techniques provide specific, sensitive and safe detection of parasites. ...