نتایج جستجو برای: γ aminobutyric acid
تعداد نتایج: 814207 فیلتر نتایج به سال:
Since the cloning of the first γ-aminobutyric acid (GABA) transporter (GAT1; SLC6A1) from rat brain in 1990, more than 50 published studies have provided structure-function information on investigator-designed rat and mouse GAT1 mutants. To date, more than 200 of 599 GAT1 residues have been subjected to mutagenesis experiments by substitution with different amino acids, and the resulting transp...
Insomnia and anxiety are worldwide medical problems. Plant extracts possessed sedative anxiolytic effect via different mechanisms included interactions with Na+ channels, γ-aminobutyric acid type A receptors, N-methyl-D-aspartate receptors chatecholamines. In the current review, Web Science, PubMed, Scopus Science Direct, were searched to investigate plants effects
BACKGROUND Propofol in the early postnatal period has been shown to cause brain cell death. One proposed mechanism for cognitive dysfunction after anesthesia is alteration of neural stem cell function and neurogenesis. We examined the effect of propofol on neural precursor or stem cells (NPCs) grown in vitro. METHODS Hippocampal-derived NPCs from postnatal day 2 rats were exposed to propofol ...
BACKGROUND Dysregulations of the major inhibitory and excitatory amino neurotransmitter systems of γ-aminobutyric acid and glutamate, respectively, have been described in patients with schizophrenia. However, it is unclear whether these abnormalities are present in subjects at ultra-high risk for psychosis. METHODS Twenty-three antipsychotic naïve subjects at ultra-high risk and 24 healthy co...
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