The new β-diketimine iPrDipnacnacH, HC(iPrCNDip)2H, Dip=2,6-iPr2-C6H3, was converted to the magnesium(I) complex [{(iPrDipnacnac)Mg}2] and reaction with 2-adamantanone (OAd) afforded ketone-1,2-diide [{(iPrDipnacnac)Mg}2(μ-OAd)]. contains first stable dianion of an aliphatic ketone electropositive metal shows OAd2− unit long C−O bond pyramidal carbon centre. DFT studies reveal anionic charge on...

In the course of the preparation of a series of ferrocenyl derivatives of diethylstilbestrol (DES), in which one of the 4-hydroxyphenyl moieties was replaced by a ferrocenyl group, the McMurry reaction of chloropropionylferrocene with a number of mono-aryl ketones unexpectedly yielded the hydroxylated ferrocenyl DES derivatives, 5a-c, in poor yields (10%-16%). These compounds showed high activi...

Reuse of chiral ruthenium catalyst in catalytic asymmetric transfer hydrogenation (CATH) has attracted attention from economic and environmental viewpoints, and reactions using ionic liquids (ILs) as solvent are recognized as one of the most useful methods for reuse of the catalyst. We synthesized (1S,2S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine (TsDPEN) derivatives with various ionic ...

Musk odorants are used widely in cosmetic industries because of their fascinating animalic scent. However, how this aroma is perceived in the mammalian olfactory system remains a great mystery. Here, we show that muscone, one musk odor secreted by various animals from stink glands, activates a few glomeruli clustered in a neuroanatomically unique anteromedial olfactory bulb. The muscone-respons...

BACKGROUND 1, 5-Benzodiazepines have been investigated extensively by organic chemists due to their medicinal and pharmacological properties. These compounds are synthesized by condensation of o-phenylenediamines with carbonyl compounds in the presence of acid catalysts. OBJECTIVES During our studies on the application of silica resin with acid functional moieties, we found that SiO2/H2SO4 mi...

moslem pregnant women are inclined to fast during the month of ramadan. ketonuria and hypoglycemia are harmful in pregnancy. the aim of this study was to find out whether clinical symptoms and/ or calorie deficiency of fasting pregnant women before eftar (ending of the daily fast) can accurately predict ketonuria and hypoglycemia. in a descriptive study, 185 volunteer fasting pregnant women in ...

Catalytic asymmetric Corey-Chaykovsky epoxidation of various ketones with dimethyloxosulfonium methylide using a heterobimetallic La-Li(3)-BINOL complex (LLB) is described. The reaction proceeded smoothly at room temperature in the presence of achiral phosphine oxide additives, and 2,2-disubstituted terminal epoxides were obtained in high enantioselectivity (97%-91% ee) and yield ( > 99%-88%) f...

The sustainable byproduct catalyzed domino strategy has been performed for the facile synthesis of α-formyloxy and acetoxy ketones via iodination/nucleophilic substitution/hydrolyzation/oxidation sequences from simple and readily available aromatic ketones/unsaturated methyl ketones.