Background: In order to select a better antibiotic choice for treatment of Pseudomonas aeruginosa infections, this study was conducted to determine the frequency of resistance to some antipseudomonal β-lactams in P. aeruginosa isolates from patients in Tehran, Iran. In addition, the relation between presence of genes known to be responsible for resist...

exo-Methylene-β-lactams were synthesized in two steps from commercially available 3-bromo-2-(bromomethyl)propionic acid and reacted with arene diazonium salts a Heck-type arylation the presence of catalytic amounts Pd(OAc)2 under ligand-free conditions. The products, arylidene-β-lactams, obtained high yields as single isomers. β-hydride elimination step Pd-catalyzed coupling reaction proceeds e...

In an approach to the biologically important 6-azabicyclo[3.2.1]octane ring system, the scope of the tandem 4-exo-trig carbamoyl radical cyclization-dithiocarbamate group transfer reaction to ring-fused β-lactams is evaluated. β-Lactams fused to five-, six-, and seven-membered rings are prepared in good to excellent yield, and with moderate to complete control at the newly formed dithiocarbamat...

Background: Antibiotics with β-Lactam rings (β-Lactams), since they were discovered, have enhanced the typical treatment for bacterial infections. Though their resistance can quickly spread on a universal scale, is primarily caused by production of β-lactamases. Hence, there serious demand to design and create new anti-β-lactamases or inhibitors. Nowadays, use β-lactamase inhibitors β-lactams r...

The four-membered cyclic amides commonly known as 2-azetidinones or β-lactams occupy a prominent place in the realm of organic and medicinal chemistry since the structure elucidation of penicillin showed the presence of β-lactam ring in it and the antibacterial activity of penicillin was attributed to the presence of β-lactam ring. The early investigations in organic chemistry were focused on d...

BACKGROUND The emergence of multi-drug resistant Gram-negatives (MDRGNs) coupled with an alarming scarcity of new antibiotics has forced the optimization of the therapeutic potential of available antibiotics. To exploit the time above the minimum inhibitory concentration mechanism of β-lactams, prolonging their infusion may improve outcomes. The primary objective of this meta-analysis was to de...

A new family of β-lactams is described that enables anionic ring-opening polymerization (AROP) to prepare nylon-3 materials bearing diverse appended functionality, including carboxylic acid, thiol, hydroxyl and secondary amine groups. Nylon-3 copolymers generated with the new β-lactams are shown to display distinctive self-assembly behavior and biological properties.

The presence of antibiotic residues in water is linked to the emergence resistance globally and necessitates novel decontamination strategies minimize residue exposure both environment food. A holistic assessment cold atmospheric pressure plasma technology (CAPP) for β-lactam removal described this study. CAPP operating parameters including jet voltage, gas composition treatment time were optim...

There is a critical need to better use existing antibiotics due to the urgent threat of antibiotic resistant bacteria coupled with the reduced effort in developing new antibiotics. β-lactam antibiotics represent one of the most commonly used classes of antibiotics to treat a broad spectrum of Gram-positive and -negative bacterial pathogens. However, the rise of extended spectrum β-lactamase (ES...