The Na,K-ATPase is a ubiquitous transmembrane pump and a specific receptor for cardiac glycosides such as ouabain and digoxin, which are used in the management of congestive heart failure (CHF). A potential role for these so-called endogenous cardiotonic steroids (CS) has been explored, and it has become apparent that such compounds are elevated and may play an important role in a variety of ph...

Alpha-1-proteinase inhibitor (α1-PI) is the most relevant protease inhibitor in the lung. Patients with hereditary deficiency of α1-PI suffer from an impaired hepatic synthesis of α1-PI in the liver and in consequence an insufficient concentration of the protease inhibitor in the lung followed by development of lung emphysema due to an impaired protease antiprotease balance and a local relative...

• ei, fi. e1 = 1⊗ E1, e2 = 1⊗ E2; f1 = 1⊗ F1, f2 = 1⊗ F2. • e0, f0, h0. e0 = t⊗ [F1, F2] = t⊗ E31. f0 = t −1 ⊗ [E1, E2] = t−1 ⊗ E13. h0 = [e0, f0] = −1⊗ (H1 +H2) + c = −1⊗ (E11 + E33) + c • H. H = 1⊗H ⊕ Cc⊕ Cd. Note that c is just the central element c = h0 + h1 + h2. • Π. α1 = 1 = 2, α1(c) = α1(d) = 0 α2 = 1 = 2, α1(c) = α1(d) = 0 θ = α1 + α2 = 1 − 3, θ(c) = θ(d) = 0 δ : δ(1⊗H) = δ(c) = 0, δ(d...

Resumo O objetivo deste estudo foi avaliar o efeito da restrição alimentar na resposta de fase aguda em equinos. Vinte cavalos foram submetidos à por 48 h enquanto outros 12 animais (controle) tiveram livre acesso água e alimento. Os monitorados, examinados amostras sangue coletadas no início (0) do com 6, 12, 18, 24, 30, 36, 42 horas alimentar. dados análise variância bidirecional medidas repe...

Cardiac α1-adrenoceptor stimulation elicits a positive inotropic effect because of myofilament Ca2+ sensitization with a small increase in Ca2+ transients predominantly mediated by α1B-adrenoceptors via the intracellular alkalinization and potential myosin light chain 2 phosphorylation. However, the α1-adrenoceptor– mediated inotropy exhibits a wide range of species-dependent variation. In addi...

α1(IV)NC1 inhibits angiogenesis by regulating MAPK activation, this biological function was partly attributed α1(IV)NC1 binding to α1β1-integrin. However, its potent antiangiogenic activity and the molecular targets of α1(IV)NC1 has not been investigated. In the present study, the regulation of MMP-2 activation by α1(IV)NC1 was evaluated. α1β1-integrin which is required for inhibition of angiog...

Beatty sequences [nα1 + β1]n∈Z and [mα2 + β2]m∈Z are recorded by two athletes running in opposite directions in a round stadium. This approach suggests a nice interpretation for well known partitioning criteria: such sequences (eventually) partition the integers essentially when the athletes have the same starting point. A remarkable observation due to S. Beatty says that if w is any positive i...

The disialic acid-containing glycosphingolipid GD3 recruited membrane transglutaminase 2 (TG2) as a signaling molecule for erythroid differentiation in human chronic myelogenous leukemia (CML) K562 cells. The α1-adrenergic receptor (α1-AR)/TG2-mediated signaling pathway regulated GD3 functions, including gene expression and production, to differentiate CML K562 cells into erythroid lineage cell...

The α1-antitrypsin (α1-AT) is a 52 kDa glycoprotein that is predominantly synthesised in the liver and secreted into the circulation, where it protects the lungs from the enzyme neutrophil elastase. α1-AT deficiency (α1-ATD) is caused by mutations in the α1-AT gene, with most cases resulting from homozygous inheritance of the Z allele (Glu342Lys). This leads to low levels of circulating α1-AT, ...

Cardiac α1-adrenoceptor stimulation elicits a positive inotropic effect because of myofilament Ca2+ sensitization with a small increase in Ca2+ transients predominantly mediated by α1B-adrenoceptors via the intracellular alkalinization and potential myosin light chain 2 phosphorylation. However, the α1-adrenoceptor– mediated inotropy exhibits a wide range of species-dependent variation. In addi...