Stathmin, a microtubule-destabilizing phosphoprotein, is highly expressed in ovarian cancer, but the pathophysiological significance of this protein in ovarian carcinoma cells remains poorly understood. This study reports the involvement of stathmin in the mTOR/HIF-1 α /VEGF pathway in ovarian clear cell adenocarcinoma (CCA) during hypoxia. HIF-1 α protein and VEGF mRNA levels were markedly ele...

The objectives of this study were to determine the effects of deoxyshikonin on lymphangiogenesis. Deoxyshikonin enhanced the ability of human dermal lymphatic microvascular endothelial cells (HMVEC-dLy) to undergo time-dependent in vitro cord formation. Interestingly, an opposite result was observed in cells treated with shikonin. The increased cord formation ability following deoxyshikonin tre...

PURPOSE The species cross-reactivity of the monoclonal antibodies infliximab, bevacizumab, and an anti-VEGF-B antibody, 2H10, in humans and rodents was determined. METHODS The binding of infliximab to human, mouse, and rat TNF-α, of bevacizumab to human, mouse, and rat VEGF-A, and of the 2H10 antibody to human, mouse, and rat VEGF-B was evaluated by ELISA. The sequence of human, mouse, and ra...

Introduction: Angiogenesis in the central nervous system is visible animal models of neuroinflammation and bone cancer pain. However, whether spinal angiogenesis exists contributes to sensitization neuropathic pain remains unclear. This study analyzes impact on Methods: Rats with chronic constriction injury (CCI) sciatic nerve underwent implantation an intrathecal catheter. Fumagillin or vascul...

Vascular endothelial growth factor (VEGF)-C is an important lymphangiogenic factor involved in the lymphangiogenesis of gallbladder carcinoma (GBC) and the lymph node metastasis of the tumor. Tumor necrosis factor (TNF)-α, a key inflammatory cytokine responding to chronic inflammation of GBC, has been reported to stimulate the expression of VEGF-C in some nonneoplastic cells. But whether TNF-α ...

background: alpha-thalassemia syndrome includes a group of hereditary anemia in which expression of alpha globin chains is decreased or absent. impaired rbc in patients with thalassemia causes vessel involvement and endothelial cell vessel disturbance. vascular endothelial growth factor (vegf) is the most important regulator for endothelial cell proliferation. so, the aim of this study is to co...

Purpose: To investigate the effect of S-adenosyl-L-methionine (SAM) on angiogenesis and fibrosis in heart rats with myocardial infarction (MI), to determine mechanism action.Methods: Sprague Dawley MI received SAM treatment (15 mg/kg) intraperitoneally. The cumulative survival (%) was recorded their rate survival. Hematoxylin-eosin staining, echocardiography, hemodynamics were also performed. I...

INTRODUCTION: Herniated discs (HDs) are a common disease responsible for symptoms in up to 40% of all patients with lower back pain. We should elucidate the precise mechanism of HD resorption and vascularization, which will result in the establishment of novel diagnostics and therapeutics for lower back pain. We previously demonstrated that VEGF (vascular endothelial growth factor) and its rece...

Slit homolog 2 (Slit2) is distributed in various tissues and participates in numerous cellular processes; however, the role of Slit2 in the regulation of angiogenesis remains controversial, since it has previously been reported to exert proangiogenic and antiangiogenic activities. The present study aimed to investigate the effects of Slit2 on vascular endothelial cell proliferation and migratio...

Aim: Investigation of the effect intraperitoneal (IP) quercetin and bevacizumab on oxygen-induced retinopathy (OIR) model in rats. Methods: In study, 28 newborn rats were used. The OIR was performed with 50/10% oxygen technique. study consisted four groups as a control group (Group I) II, III, IV). IP injection applied to all postnatal day (PND) 14. Groups I II 0.9% NaCl, Group III bevacizumab...