Măng cụt (Garcinia mangostana L.) là một loại trái cây phổ biến, trong khoảng 40 xanthon được tìm thấy vỏ quả, các mangostin (gồm α-mangostin, β-mangostin và γ-mangostin) đang rất quan tâm. Đề tài đã thực hiện khảo sát yếu tố ảnh hưởng đến quá trình chiết xuất thông qua sơ bộ bằng sắc ký lớp mỏng định lượng polyphenol cao thu HPLC, với mục tiêu lựa chọn số kỹ thuật quy mô phòng thí nghiệm giàu ...

Cancer chemoprevention is a promising strategy taken to block, reverse, or retard carcinogenesis. α-Mangostin, a natural xanthone isolated from the pericarps of mangosteen, represents one of the most studied chemopreventive agents. This compound has been reported to interfere with all the major stages of carcinogenesis: initiation, promotion, and progression. A number of mechanisms have been pr...

5-fluorouracil (5-FU) is a chemotherapeutic agent commonly used for treatment of solid tumors, including colorectal cancer. However, chemoresistance against 5-fluorouracil (5-FU) often limits its success for chemotherapy and, therefore, finding out appropriate adjuvant(s) that might overcome chemoresistance against 5-FU bears a significant importance. In the present study, we have found that α-...

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. The α-mangostin in mangosteen pericarp extract can inhibit M. tuberculosis growth. This study examined the potency of α-mangostin in mangosteen pericarp extract to inhibit 38-kDa and Ag85 protein secretion from M. tuberculosis H37Rv. The samples used in this study were divided into three independent variable groups...

Diabetic vascular complications result from high-glucose induced vascular endothelial cell dysfunction. There is an emerging need for novel drugs with vascular endothelial cell protective effects for the treatment of diabetic vascular complications. The present study aimed to investigate the protective effect of α-mangostin against high-glucose induced apoptosis of cultured human umbilical vein...

Background: Diabetes Mellitus (DM) is a complex chronic disease characterized by increased blood glucose. The incidence of this rising, especially type 2 diabetes which caused insulin resistance in the body. SUR1-Pancreatic KATP Channel receptor as an antidiabetic target because its inhibition process can increase production so that it reduce glucose people with diabetes. Objective: This study ...

The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs were obtained through semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the ...

Phytochemical and biological studies were carried out the stem bark of Cratoxylum arborescens collected from Sarawak, Malaysia. Chromatographic separation of the plant extracts led to the isolation of three xanthones, -mangostin (1), -mangostin (2) and fuscaxanthone C (3) together with the commom stigmasterol. The structural elucidation of the compound was determined by detail spectroscopic a...

The microbial contamination in food packaging have been a major concern that paved the way for the search for natural based new anti-microbial agents, such as modified α-mangostin. In the present work, twelve synthetic analogs were obtained via semi-synthetic modification of α-mangostin by Ritter reaction, reduction by palladium-carbon (Pd-C), alkylation, and acetylation. The evaluation of the ...

We investigated the anti-cholangiocarcinoma effect of α-mangostin from Garcinia mangostana pericarp extract (GM) in a human cholangiocarcinoma (CCA) cell line and a hamster CCA allograft model. In vitro, human CCA cells were treated with GM at various concentrations and for different time periods; then cell-cycle arrest and apoptosis were evaluated using flow cytometry, and metastatic potential...