نتایج جستجو برای: zo 1
تعداد نتایج: 2752975 فیلتر نتایج به سال:
PURPOSE A culture model was used to examine the development of tight junctions in the retinal pigment epithelium (RPE). METHODS Chick RPE was isolated on embryonic day 7 (E7), E10 or E14 and cultured on laminin-coated filters. Barrier properties were stimulated with E14 retinal conditioned medium. Morphology was characterized by confocal microscopy. Permeability was determined by measuring th...
The structure and function of both adherens (AJ) and tight junctions (TJ) are dependent on the cortical actin cytoskeleton. The Zonula Occludens (ZO)-1 and -2 proteins have contextdependent interactions with both junction types and bind directly to F-actin and other cytoskeletal proteins, suggesting they might regulate cytoskeletal activity at cell junctions. To address this hypothesis, we gene...
Assembly and sealing of the tight junction barrier are critically dependent on the perijunctional actin cytoskeleton, yet little is known about physical and functional links between barrier-forming proteins and actin. Here we identify a novel functional complex of the junction scaffolding protein ZO-1 and the F-BAR-domain protein TOCA-1. Using MDCK epithelial cells, we show that an alternative ...
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