Sertoli cell proliferation is attenuated before attaining puberty and the number is fixed in adult testes. Sertoli cells determine both testis size and daily sperm production by providing physical and metabolic support to spermatogenic cells. Polychlorinated biphenyls (PCBs) exposure disrupts functions of Sertoli cells causing infertility with decreased sperm count. On the other hand, lycopene ...

Tomato hot pot sauce (THPS) at different storage temperatures (0, 25, and 37°C) and with two kinds of packaging for 120 days was investigated in this study. High performance liquid chromatography was employed for detecting lycopene and 5-hydroxymethylfurfural (HMF). The changes of lycopene and HMF during storage were regressed with kinetic equation of both zero-order and first-order models, and...

Increased prevalence of non-alcoholic fatty liver disease (NAFLD) is one of the consequences of the current obesity epidemic. NAFLD is a major form of chronic liver disease that is highly prevalent in obese and overweight adults and children. Nonalcoholic steatohepatitis (NASH) is the severe form of NAFLD, and uncontrolled inflammation as displayed in NASH has been identified as one of the key ...

Lycosome technology represents a new development in the modern biotechnology directed at improvement of bioavailability of nutraceuticals and pharmaceuticals as well as their organ-specific delivery. Lycosome technology exemplifies a nanomicroencapsulation methodology using unique physicochemical properties of lycopene as an organic compound. Lycopene is a symmetrical non-polar tetraterpene com...

background: cylophosphamide is used alone or in combination with other drugs for treatment of neoplastic diseases. hemorrhagic cystitis is a major potential toxicity and dose limiting side effect of cyclophosphamide. the aim of this study was to evaluate the effects of lycopene compared with some antioxidants for the prevention of cyclophosphamide induced hemorrhagic cystitis in rats.   methods...

sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. the aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. these group...

nonenzymatic glycation of low density lipoprotein (ldl) is a reaction of glucose and other reducing sugars with apolipoprotein b100 (apo-b100) lysine residues. in diabetes, this reaction is greatly accelerated and is important in the pathogenesis of diabetic complications. the objective of this study was to investigate in vitro effects of ?-tocopherol, ascorbic acid and lycopene on ldl glycatio...

Colour mutants of the tomato pathogen, Coynebacterium michiganense, provided an opportunity to determine the nature of this micro-organism's pigments, and the effect of mutation and nutrition thereon. The major pigments of C. michiganense are carotenoids. The parent and mutant strains show distinct qualitative differences in pigment synthesis. The naturally occurring yellow parent type produces...

BACKGROUND Consumption of lycopene through tomato products has been suggested to reduce the risk of prostate cancer. Cellular adhesion and migration are important features of cancer progression and therefore a potential target for cancer interception. In the present study we have examined the in vitro effect of lycopene on these processes. METHODS Prostate cancer cell lines PC3, DU145 and imm...

Consumption of lycopene, a carotenoid without provitamin A activity, has been associated with a lower risk of prostate and breast cancer. Lutein is another carotenoid that may be associated with a reduced risk of age-related macular degeneration, the leading cause of blindness in adults 65 years of age and older. Bioactive compounds such as lycopene and lutein, derived from natural plant source...