Abstract Small GTPases of the Rab family play important roles in membrane trafficking and autophagy. Previous studies have shown that small GTPase Sec4 is involved vegetative growth, protein secretion, pathogenicity fungal phytopathogens. In this study, BcSec4, an ortholog yeast Sec4p protein, was characterized Botrytis cinerea . The ΔBcSEC4 mutant produces many abnormal conidiophores; it thus ...

Background: The tumor immune microenvironment influences evolution in non-small cell lung cancer (NSCLC). Yet, the prognostic value of programmed death-ligand 1 (PD-L1) epidermal growth factor receptor (EGFR)-mutant NSCLC remains controversial. Additionally, studies Filipinos with EGFR-mutant remain unexplored to this day.

Background:Pseudomonas aeruginosa is a gram negative non facultative bacterium and one of the members of normal flora in different sites of body in healthy humans.this bacterium can resist in fluids and hospital environments for a long time.Pseudomonas aeruginosa has two systems for glucose uptake:a low affinity oxidative pathway and a high affinity phosohorylative pathway.Although the role of ...

Thermostable chitinases are useful for industrial and biotechnological applications. This paper reports the stabilization of chitinase from Serratia marcescens B4A through rational mutagenesis. Changing of Ser 390 to Ile in S. marcescens. The stabilization was enhanced through entropic stabilization by reduction of the loop length and also by increasing of the beta chain length. With this repla...

There is no functional annotation for the majority of the several hundreds of receptor-like kinases in plants. A direct way of inferring the function of these proteins is to study the phenotype that results from loss of function mutants such as T-DNA mutant lines. In this research a function (phenotype) to At2g37050 gene that encodes a receptor like kinase in Arabidopsis T-DNA line was...

Three rat sarcoma (RAS) gene isoforms, KRAS, NRAS, and HRAS, constitute the most mutated family of small GTPases in cancer. While development targeted immunotherapies has led to a substantial improvement overall survival patients with non-KRAS-mutant cancer, RAS-mutant cancers have an poorer prognosis owing high aggressiveness tumors. KRAS mutations are strongly implicated lung, pancreatic, col...