Foundations face two competing imperatives when they commit to advancing equity. On the one hand, are counseled support and follow lead of community-based groups that on front lines social change. other also being challenged use their power influence act boldly change inequitable structures, policies, institutions. These orientations, yin yang, can take a foundation in different directions thus...

Role of Yin and Yang in Diurnal Blood Pressure Variation for Cardiovascular Disease To the Editor: We read with great interest the work by Verdecchia et al, which reported that, in initially untreated subjects with hypertension, a blunted day-night blood pressure (BP) dip was associated with a blunted morning BP surge and vice versa. In these subjects, a blunted morning BP surge was an independ...

Ancient Chinese philosophers discovered Yin and Yang the laws of movement during their exploration practice nature more than two thousand years ago, applied them to life, science, philosophy medicine, playing an important role in achievement ancient civilization. Through historical changes, yin yang have gradually been regarded as a concept or theory, thus making it difficult for people underst...

Note: The author of this paper is not an M.D. The contents of this paper are based on the listed references and are offered for educational and informational purposes only. This article is meant to bring attention to a timely treatment therapy concept that should be considered; it is not meant to be a complete literature review for either immunotherapy or vaccine therapy. Patients should refer ...

Mitochondria are primarily responsible for producing ATP via oxidative phosphorylation in the inner mitochondrial membrane. Because of the high energy demand of the heart, mitochondria comprise at least 30% of the myocyte volume. Mitochondria also play central roles in both necrosis and apoptosis and can quickly change from a source of energy for sustaining contraction to an organelle that prom...

The rapid accumulation of signaling and repair factors in the vicinity of DNA lesions is an integral part of the cellular DNA damage response (DDR) to DNA double-strand breaks (DSBs).1,2 This is initiated by posttranslational modifications of core histones, to which various effector proteins bind. The priming modification is ATM-mediated phosphorylation of histone H2AX at Ser-139 (γ-H2AX), a ma...

A patient who is immunosuppressed is susceptible to mycobacterial infection: are you surprised? Before you jump to conclusions, you might wish to clarify the nature and extent of immunosuppression, and whether it is through disease, therapy, or both, reserving judgement until you know more. Patients are often concerned about immunosuppressive effects of inhaled and oral corticosteroids. Asthmat...

In ancient Chinese philosophy, Yin-Yang describes two contrary forces that are interconnected and interdependent. This concept also holds true in microbial cell factories, where Yin represents energy metabolism in the form of ATP, and Yang represents carbon metabolism. Current biotechnology can effectively edit the microbial genome or introduce novel enzymes to redirect carbon fluxes. On the ot...

While hippocampal and cortical mechanisms of memory consolidation have long been studied, their interaction is poorly understood. We sought to investigate potential interactions with respect to trace dominance, strengthening, and interference associated with postencoding novelty or sleep. A learning procedure was scheduled in a watermaze that placed the impact of novelty and sleep in opposition...