Osteosarcoma is a common cancer type among the youth population and usually develops in growing bones. Approximately twenty percent of osteosarcoma cases show tendency to metastases patients with have low survival rate after treatment. RANK/RANKL/OPG key regulator triad bone remodeling play critical roles tumourigenesis osteosarcoma. Anti-proliferative activity gambogic acid was determined Saos...

This study determined the effect of thiourethane-functionalized fillers (TU) on antimicrobial properties, cytotoxicity, degree conversion (DC), water sorption (Wsp) and solubility (Wsl) experimental composites. TU-modified were added at different ratios in composites: 0 (Control-TU0), 25% (TU25), 50% (TU50), 75% (TU75) 100wt% (TU100). The properties detected through exhaustion test counting Str...

In this study we have realized the need for an organ culture tooth in situ model to simulate structure especially attachment apparatus. The importance of such a is open avenues investigating regeneration complex and tissues reduce experimental animals dental materials treatments future. aim was develop porcine novel bioreactor suitable future studies periodontal regeneration, including applicat...

The enormous bioactive components of different species from marine habitats make them attractive candidates for the discovery new therapeutic active substances in several diseases such as cancer. Sea sponge and tunicate materials are ideal sources chemotherapeutics various cancers due to their rich metabolites. fundamental purpose current study is investigate cytotoxic activity methanolic crude...

Chitosan oligosaccharides (ChOSs) are the reduced products of chitosan prepared by chemical or enzymatic hydrolysis. The greater solubility and low viscosity ChOSs interest. present study was first to evaluate toxicity oligosaccharide lactate (ChOSlac) in human blood. For this purpose, possible oxidative effects ChOSlac whole blood (hWB) cell viability membrane integrity on lymphocytes (LYMs) w...

The increasing rate of fungal infections causes global problems not only in human healthcare but agriculture as well. To combat pathogens limited numbers antifungal agents are available therefore alternative drugs needed. Antimicrobial peptides potent candidates because their broad activity spectrum and diverse mode actions. model legume Medicago truncatula produces >700 nodule specific cyst...

OBJECTİVE: In this study, we aimed to examine of antileishmanial effect curcumin-mediated sonodynamic (SDT), photodynamic (PDT), and sonophotodynamic (SPDT) therapies with a potential mechanism against the Leishmania tropica (L.tropica) promastigotes. SPDT is new treatment modality for Leishmaniasis that combines therapies. Curcumin natural antiinflammatory agent has been used treating medical ...

Background: Neuroblastoma (NB) is a rare childhood cancer but accounts for 15% of paediatric deaths. MYCN amplification and/or ATM loss through 11q deletion may cause an increase in replication stress (RS) substantial proportion (~80%) high-risk NB. RS creates dependency on ATR-mediated S and G2 checkpoint control. This study aimed to determine if or identifies cells which are sensitive ATR inh...