نتایج جستجو برای: xrcc2
تعداد نتایج: 204 فیلتر نتایج به سال:
OBJECTIVES We have undertaken a comprehensive study of common polymorphisms in genes of DNA repair, exploring both the risk of developing colorectal cancer and the prognosis of patients. METHODS Subjects from a case-control study (377 cases and 329 controls) designed to assess gene-environment interactions were genotyped by use of an oligonucleotide microarray and the arrayed primer extension...
Prostate cancer is among the leading causes of morbidity and mortality from cancer in men. Epidemiologic data suggest that dominant susceptibility genes may be responsible for 5%-10% of all of the cases and 30-40% of early onset cases. Familial clustering of prostate cancer is observed in 10-20% of men with prostate cancer. Scandinavian study of twins suggests that the heritability of prostate ...
BACKGROUND The International Lung Cancer Consortium was established in 2004. To clarify the role of DNA repair genes in lung cancer susceptibility, we conducted a pooled analysis of genetic variants in DNA repair pathways, whose associations have been investigated by at least 3 individual studies. METHODS Data from 14 studies were pooled for 18 sequence variants in 12 DNA repair genes, includ...
Bacterial RecA and its yeast orthologue RAD51 are the founding members of the RecA/RAD51 protein family, which plays a crucial role in DNA repair by homologous recombination (for review see Kawabata et al., 2005). After DNA ends are resected at the site of a DNA break, these proteins form a nucleoprotein fi lament on the single-stranded DNA and catalyze a strand invasion and strand exchange rea...
Bladder cancer is associated with tobacco smoking and occupational exposure. The repair of DNA damage has a key role in protecting the genome from the insults of cancer-causing agents. We analyzed 13 polymorphisms in seven DNA repair genes belonging to different repair pathways [X-ray repair cross-complementing group 1 (XRCC1): 26304C>T, 26651A>G, 28152A>G; xeroderma pigmentosum-D (XPD): 23591A...
For a quantum mechanical system with broken supersymmetry, we present a simple method of determining the ground state when the corresponding energy eigenvalue is sufficiently small. A concise formula is derived for the approximate ground state energy in an associated, well-separated, asymmetric double-well-type potential. Our discussion is also relevant for the analysis of the fermion bound sta...
Homologous recombinational repair (HRR) restores chromatid breaks arising during DNA replication and prevents chromosomal rearrangements that can occur from the misrepair of such breaks. In vertebrates, five Rad51 paralogs are identified that contribute in a nonessential but critical manner to HRR proficiency. We constructed and characterized a knockout of the paralog Rad51D in widely studied C...
In this paper we consider the numerical computation of band gaps in photonic crystal fibres. We approximate the solution to a variational eigenvalue problem using the planewave expansion method (spectral Galerkin method). As well as presenting implementation and error analysis results we consider solving a modified problem where the piecewise constant coefficient function is replaced with a smo...
BRCA1 and BRCA2 are the most well-known breast cancer susceptibility genes. Additional genes involved in DNA repair have been identified as predisposing to breast cancer. One such gene, RAD51C, is essential for homologous recombination repair. Several likely pathogenic RAD51C mutations have been identified in BRCA1- and BRCA2-negative breast and ovarian cancer families. We performed complete se...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید