searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggesstions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Hi...

A protease inhibitor has been purified from platelets by ammonium sulfate fractionation, QAE Sephadex chromatography, Sephadex G-200 gel filtration, and affinity chromatography on concanavalin A-Sepharose to apparent homogeneity on disc gel electrophoresis. The following properties of the inhibitor suggest its relationship to plasma a1 -antitrypsin: antigenic identity with a antitrypsin, molecu...

BACKGROUND Common variable immunodeficiency (CVID) is the most common clinically severe primary immunodeficiency and comprises a heterogeneous group of patients with recurrent severe bacterial infections due to the failure to produce IgG antibodies after exposure to infectious agents and immunization. Diagnostic recommendations for antibody failure include assessment of isoagglutinins. We have ...

Interacting solutes form mUltiple associates and usually mask each other in ensemble characterization. They are susceptible to preparation artefacts in the single-molecule techniques commonly applied. To overcome the problem of bulk characterization of a single-walled carbon nanotube (CNT) dispersion with a novel surfactant-intercalant mixture, we obtain color movies of fractionation under extr...

Bruton's tyrosine kinase (Btk) is a Tec family non-receptor tyrosine kinase that plays a critical role in immune signaling and is associated with the immunological disorder X-linked agammaglobulinemia (XLA). Our previous findings showed that the Tec kinases are allosterically activated by the adjacent N-terminal linker. A single tryptophan residue in the N-terminal 17-residue linker mediates al...

David Shai Ellis,1 Yao-Bo Huang,2,3 Paul Olalde-Velasco,2 Marcus Dantz,2 Jonathan Pelliciari,2 Gil Drachuck,1 Rinat Ofer,1 Galina Bazalitsky,1 Jorge Berger,4 Thorsten Schmitt,2 and Amit Keren1,* 1Physics Department, Technion-Israel Institute of Technology, Haifa 32000, Israel 2Swiss Light Source, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland 3Beijing National Laboratory for Condense...

searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggesstions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Hi...

Nutrition is an important factor that influences immunity, and nutritional deficiencies can impair resistance to infections. Malnutrition is the most common cause of immunodeficiency worldwide. Trace elements such as zinc, selenium, iron, and copper can influence several components of immunity. Primary antibody deficiency disorders are a group of disorders characterized by an unusual susceptibi...

BACKGROUND While primary immunodeficiencies (PID has been recognized in the west for decades, recognition has been delayed in the third world. This study attempts to detail the spectrum of PID, the therapy provided, and constraints in the diagnosis and treatment in a middle income country such as Sri Lanka. METHODS Nine hundred and forty two patients with recurrent infections and features sug...

The Journal of Infectious Diseases® 2017;215:486–7 Nitazoxanide was commenced at a dose of 500 mg twice daily. It was well tolerated with no adverse effects. Initially, an improvement in frequency and severity of diarrhea was noted. Results of PCR analysis of stool specimens became negative for norovirus; however, the MS2 bacteriophage used as an internal control added to the patient sample was...