نتایج جستجو برای: xenograft models
تعداد نتایج: 924797 فیلتر نتایج به سال:
NXP800 (CCT361814) is a Heat Shock Factor (HSF1) pathway inhibitor currently being studied in phase 1 clinical trial (NCT05226507). demonstrated substantial antitumor activity cancer cell lines of different histologies, including ovarian clear and endometrioid carcinoma (OCCC EOC), gastric carcinoma, haematological cancers. Loss function ARID1A was identified as predictive marker for response t...
Introduction Two breast cancer xenograft models have been established from human breast cancer patients and ortothopically xenografted in female SCID mice (1). The models represent a basal-like (poor prognosis) and a luminal-like (better prognosis) genetic profile. Using HR MAS H MR spectroscopy, it has been shown that these two models have distinct metabolic profiles (2). It is well known that...
Cyclin-dependent kinases (CDK), and their regulatory cyclin partners, play a central role in eukaryotic cell growth, division, and death. This key role in cell cycle progression, as well as their deregulation in several human cancers, makes them attractive therapeutic targets in oncology. A series of CDK inhibitors was developed using Astex's fragment-based medicinal chemistry approach, linked ...
ownload examined whether potent vascular endothelial growth factor (VEGF) blockade mediated by aflibercept, y VEGF receptor (VEGFR) 1/2 moiety with stronger affinity for VEGF than bevacizumab, resulted in kemia effects and enhanced the efficacy of systemic chemotherapy. The efficacy of aflibercept alone combination with doxorubicin was evaluated in human VEGF-expressing acute myeloid leukemia )...
Purpose: Immunodeficient mice transplanted with subcutaneous tumors (xenograft or allograft) are widely used as a model of preclinical activity for the discovery and development of anticancer drug candidates. Despite their widespread use, there is a widely held view that these models provide minimal predictive value for discerning clinically active versus inactive agents. To improve the predict...
Endocrine therapy has been highly effective for the treatment of estrogen receptor-positive breast cancer, but endocrine resistance develops in a significant proportion of patients. In an effort to develop novel therapeutic strategies for the treatment of endocrine-resistant breast cancer, we have evaluated a potent and specific MDM2-p53 interaction inhibitor, MI-77301, which has been advanced ...
Difficulties of drug delivery across the blood-brain barrier (BBB) and failure to eliminate cancer stem cells (CSCs) are believed to be the major causes of tumor recurrences in children with medulloblastoma (MB). Seneca Valley virus-001 (SVV-001) is a naturally occurring oncolytic picornavirus that can be systemically administered. Here, we report its antitumor activities against MB cells in a ...
Common preclinical models for testing anticancer treatment include cultured human tumor cell lines in monolayer, and xenografts derived from these cell lines in immunodeficient mice. Our goal was to determine how similar the xenografts are compared with their original cell line and to determine whether it is possible to predict the stability of a xenograft model beforehand. We studied a selecti...
Plasmonic nanomaterials are poised to impact the clinical management of cancer through their ability to convert externally applied energy into localized heat at sites of diseased tissue. However, characterization of plasmonic nanomaterials as cancer therapeutics has been limited to xenograft models, creating a need to extend these ̄ndings to more clinically relevant models of cancer. Here, we ev...
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