Pharmacological therapy for irritable bowel syndrome (IBS) has not been established. In order to find candidate drugs for IBS with diarrhea (IBS-D), we screened a compound library of drugs clinically used for their ability to prevent stress-induced defecation and visceral hypersensitivity in rats. We selected the bronchodilator aminophylline from this library. Using a specific inhibitor for eac...

This article describes methods for online model-based diagnosis of subsystems of the advanced life support system (ALS). The diagnosis methodology is tailored to detect, isolate, and identify faults in components of the system quickly so that fault-adaptive control techniques can be applied to maintain system operation without interruption. We describe the components of our hybrid modeling sche...

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Nitric oxide (NO) is involved in the pathogenesis of cerebral ischemic injury. Here, we investigated effects aging on NO production during ischemia-reperfusion (IR). Male Wister rats (WRs) were assigned to 12-month-old (older; n = 5) and 3-month-old (younger; 7) groups. Similarly, male spontaneous hypertensive (SHRs) allocated 6) 8) After anesthesia, their was monitored using vivo microdialysis...

We present a novel hierarchical Bayesian quantile regression model to estimate how precipitation scales with temperature depending on season, weather regime (WR; i.e., large-scale patterns of atmospheric circulation), and percentile. The approach develops regional scaling estimates by partially pooling data across sites, accounting for uncertainty stemming from variable record lengths. Results ...

For the purpose of probabilistic fracture mechanics estimation in field reliability analysis pressure vessels and piping, a method by using SINTAP (Structural INTegrity Assessment Procedures for European Industry) is developed. Monte Carlo simulation (MCS) applied to investigate influence both uncertainties random parameters inspection strategies on failure probability (FP). A sensitivity with ...

We combine new CCD UBV photometry and spectroscopy with that from the literature to investigate 19 Magellanic Cloud OB associations that contain Wolf-Rayet (WR) and other types of evolved massive stars. Our spectroscopy reveals a wealth of newly identified interesting objects, including early O-type supergiants, a high mass double-lined binary in the SMC, and, in the LMC, a newly confirmed LBV ...

©Jo ur nal of Cli ni cal Re se arch in Pe di at ric En doc ri no logy, Pub lis hed by Ga le nos Pub lis hing. Dear Editor, Wolcott-Rallison syndrome (WRS; Online Mendelian Inheritance in Man 226980) is an autosomal recessively inherited disorder characterized by neonatal insulin-dependent diabetes mellitus, skeletal dysplasia (epiphyseal dysplasia), acute hepatic and/or renal dysfunction, exocr...