15 If today you want to keep up with basic and clin‐ ical research, you need to concentrate on a very small field and reach tremendous depths in this very field. And, actually, life is too short to also accumulate the knowledge necessary to do mean‐ ingful scientific work even on closely related top‐ ics. Hence, specialization is inevitable not only in research; it was a prerequisite for the de...

Twenty-five years ago, Dennis Egan published a review on the impact of individual differences in human-computer interaction, where he claimed that users are more diverse than designs are [5]. While being cited frequently, this claim has not been tested since then. An efficient research design for separating and comparing variance components is presented, together with a statistical model to tes...

Anti-citrullinated protein autoantibodies (ACPAs) are the major autoantibodies in rheumatoid arthritis (RA). Anti-citrullinated protein autoantibodies are directed against different citrullinated antigens, including filaggrin, fibrinogen, vimentin, and collagen. Presence of ACPA is associated with joint damage and extra-articular manifestations, suggesting that ACPAs are most likely pathogenic ...