نتایج جستجو برای: wnt pathway

تعداد نتایج: 325509  

2010
Lea Goentoro Marc W. Kirschner

In the canonical Wnt pathway, binding of the Wnt ligand to its transmembrane receptors leads to an inhibition of the degradation of β-catenin; as a result, β-catenin accumulates to a point where it activates target genes. Using mathematical modeling and experiments in mammalian cells, we examined the robustness of the β-catenin response to Wnt stimulation. We found that the final (post-Wnt) lev...

2016
Huai-Xiang Hao Xiaomo Jiang Feng Cong

Aberrant activation of the Wnt/β-catenin pathway is frequently found in various cancers, often through mutations of downstream components. Inhibiting β-catenin signaling in tumors with downstream pathway mutations remains challenging, due to a lack of favorable targets. On the other hand, targeting upstream components of the Wnt pathway is rather straightforward. However, it is difficult to ide...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2011
Waldo Cerpa Abigail Gambrill Nibaldo C Inestrosa Andres Barria

Wnt ligands are secreted glycoproteins controlling gene expression and cytoskeleton reorganization involved in embryonic development of the nervous system. However, their role in later stages of brain development, particularly in the regulation of established synaptic connections, is not known. We found that Wnt-5a acutely and specifically upregulates synaptic NMDAR currents in rat hippocampal ...

2004
Hue H. Luu Ruiwen Zhang Rex C. Haydon Elizabeth Rayburn Quan Kang Weike Si Jong Kyung Park Hui Wang Ying Peng Wei Jiang Tong-Chuan He

Wnt proteins are a large family of secreted glycoproteins. Wnt proteins bind to the Frizzled receptors and LRP5/6 co-receptors, and through stabilizing the critical mediator β-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. Deregulation of the canonical Wnt/β-catenin signaling pathway, mostly by inactivating mutati...

2012
Hans Otto Kalkman

Microdeletion and microduplication copy number variations are found in patients with autism spectrum disorder and in a number of cases they include genes that are involved in the canonical Wnt signaling pathway (for example, FZD9, BCL9 or CDH8). Association studies investigating WNT2, DISC1, MET, DOCK4 or AHI1 also provide evidence that the canonical Wnt pathway might be affected in autism. Pre...

2014
E.M. Oxford C.G. Danko P.R Fox B.G. Kornreich N.S. Moïse

BACKGROUND Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited myocardial disease with high prevalence in the Boxer dog population. It is characterized by replacement of the myocardium with fatty or fibro-fatty tissue. Several mechanisms for the development of ARVC have been suggested, including dysfunction of the canonical Wnt pathway, which is linked to many cellular functi...

Journal: :Cancer science 2010
Lei Wang Hua Li Qi Chen Tengfang Zhu Hongguang Zhu Li Zheng

Wnt signaling plays key roles in development, cell growth, differentiation, polarity formation, neural development, and carcinogenesis. DIX Domain Containing 1 (DIXDC1), a novel component of the Wnt pathway, was recently cloned. DIXDC1 is the human homolog of Ccd1, a positive regulator of the Wnt signaling pathway during zebrafish neural patterning. Little has been known about DIXDC1 gene expre...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Yuko Komiya Noopur Mandrekar Akira Sato Igor B Dawid Raymond Habas

Precise control of the canonical Wnt pathway is crucial in embryogenesis and all stages of life, and dysregulation of this pathway is implicated in many human diseases including cancers and birth defect disorders. A key aspect of canonical Wnt signaling is the cytoplasmic to nuclear translocation of β-catenin, a process that remains incompletely understood. Here we report the identification of ...

2017
Mohamad Rima Marwa Daghsni Anaïs Lopez Ziad Fajloun Lydie Lefrancois Mireia Dunach Yasuo Mori Philippe Merle Juan L. Brusés Michel De Waard Michel Ronjat

The β4 isoform of the β-subunits of voltage-gated calcium channel regulates cell proliferation and cell cycle progression. Herein we show that coexpression of the β4-subunit with actors of the canonical Wnt/β-catenin signaling pathway in a hepatoma cell line inhibits Wnt-responsive gene transcription and decreases cell division, in agreement with the role of the Wnt pathway in cell proliferatio...

2013
Chad A. Bousman Stephen J. Glatt Sharon D. Chandler James Lohr William S. Kremen Ming T. Tsuang Ian P. Everall

Genes in the Wnt (wingless)/ β -catenin signaling pathway have been implicated in schizophrenia pathogenesis. No study has examined this pathway in the broader context of psychosis symptom severity. We investigated the association between symptom severity scores and expression of 25 Wnt pathway genes in blood from 19 psychotic patients. Significant correlations between negative symptom scores a...

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