Formation and Reactions of Acetals and Related Species . . . . . . . . . . . . . . 1 Reactions of Glucosides and Nucleosides . . . . . . . . . . . . . . . . . . . . . . . . . 4 Reactions of Ketenes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Formation and Reactions of Nitrogen Derivatives . . . . . . . . . . . . . . . . . . . 7 Imines . . . . . . . . . . . . ...

Since the discovery of organic azides by Peter Griess more than 140 years ago, numerous syntheses of these energy-rich molecules have been developed. In more recent times in particular, completely new perspectives have been developed for their use in peptide chemistry, combinatorial chemistry, and heterocyclic synthesis. Organic azides have assumed an important position at the interface between...

An open-cage fullerene incorporating phosphorous ylid and carbonyl group moieties on the rim of orifice can be filled with gases (H2, He, Ne) in solid state, cage opening then contracted situ by raising temperature to complete an intramolecular Wittig reaction, trapping atom or molecule inside. Known transformations conversion product C60 containing endohedral species. As well as providing impr...

Georges Darzen's name is absent from the Dictionary of Scientific Biography. This is a regrettable omission, on three grounds. He was a creative organic chemist, to whom we owe both the thionyl chloride conversion of alcohols into chlorides and the "Darzens reaction"—an addition-fragmentation which can be seen as the forerunner to the Wittig reaction. He was a perceptive observer of the scienti...

11-Chloro-3-methoxy-2-undecenal was synthesized from 8-bromooctanol, and an annelation reaction with this aldehyde and ethyl acetoacetate proceeded to give the ethyl 6-(8-chlorooctyl)salicylate. Ethyl 6-(8-chlorooctyl)salicylate was converted to ethyl 6-(7-formylheptyl)-2-methoxybenzoate through the iodide after protection of the phenolic hydroxyl group. Finally, the Wittig reaction with the al...