Using quantitative autoradiography, we investigated the entry over 90 min of |l4C]methotrexate (MTX) into Q gliomas implanted bilaterally into Wistar rat brains. The [I4C]MTX was administered into the right carotid artery, yielding ipsilateral "arterial" brain and tumor concentra tions and contralateral "systemic'" concentrations. In a separate group of tumor-bearing rats, mannitol 1.6 M was gi...

Aim—To determine if â defensins are expressed in the anterior segment of the eye and to determine the temporal pattern of expression using a real time semiquantitative reverse transcription polymerase chain reaction (RT-PCR). Methods—Ocular tissue (corneal epithelium, conjunctiva, iris, and lens capsule) was collected from 23 patients undergoing surgery. Serial corneal or conjunctival impressio...

Cholecystokinin (CCK) is a growth factor for normal pancreas. Nu merous studies also suggest that CCK promotes pancreatic carcinogenesis in the rat. Our previous studies suggested that growth of preneoplastic pancreatic foci was stimulated by CCK more than that of normal pan creas. We hypothesized that such differential growth might be due to increased numbers of CCK receptors in neoplastic tis...

          The aim of this paper is to simulate the effects of some macroeconomic policy tools on production and inflation of Iran by the current worldwide financial and real crisis. The theoretical framework of the analysis is based on the so-called ‘IMF/World Bank Integrated Model’ which is the synthesis (a merger) of the basic monetary approach of the Balance of Payments used at t...

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Glucocorticoids (GCs) induce apoptosis in lymphoid cells that contain functional GC receptors (GRs). However, GC resistance often is seen in cells with demonstrable GRs; one such line is CEM-C1. We have tested the hypothesis that positive interactions between GC and cyclic AMP (cAMP) regulate GC actions in CEM clones. Treatment of both GC-resistant CEM-C1 [resistant to 1 JIMdexamethasone (Dex)]...

Low concentrations of chloride facilitate the conversion of cisplatin (CDDP) to cytotoxic species in aqueous solution. Low urine chloride concentrations increased CDDP-induced renal injury, while high urine chloride concentrations were protective. Sprague-Dawley rats drinking 1.2% sodium phosphate or 1.4% sodium bicarbonate and consuming low-chloride rat diet for 3 days excreted urine with a me...

background: cystatin c (cys c) has been implicated as a prognostic marker in cardiovascular disease. the aim of this study was to evaluate the value of cys c as a marker of acute kidney injury (aki) in acute heart failure (ahf), the impact of cys c and n-terminal probrain natriuretic peptides (nt-probnp) on in-hospital and 12 months mortality were also investigated. materials and methods: a tot...

Sustainable development is a Controversial concept which has been considered over the three decades. It is comprehensive development and includes all of dimensions as “economic’’, “social’’ and ‘‘environmental’’. In economic objective, it requires substantial economic change that can be brought about by investment and trade. They are effective factors of sustainable developm...

To elucidate the significance of tRNA modification for human lymphoid maturation and malignant transformation, the amount of tRNAs having guanosine in place of queuosine, i.e., (Q-)tRNA, was determined in several human lymphomas and leukemias by exchanging the respective unmodified guanosine residue for [3H]guanine, a reaction catalyzed by a specific tRNA transglycosylase from Escherichia coli....