UNLABELLED Depression is common in reproductive age women, and continued pharmacologic treatment of depression during pregnancy may be necessary to prevent relapse, which could be harmful for both the fetus and the mother. Although data on drug safety are imperfect and incomplete, the benefits of antidepressant therapy during pregnancy generally outweigh the risks. Neonates who are exposed to a...

Activity of the mesolimbic dopaminergic system was investigated in rats withdrawn from chronic ethanol administration by single-cell extracellular recordings from dopaminergic neurons of the ventrotegmental area, coupled with antidromic identification from the nucleus accumbens, and by microdialysis-technique experiments in the nucleus accumbens. Spontaneous firing rates, spikes per burst, and ...

With increasing maternal drug abuse, the paediatrician must be ever alert to the possibility that symptoms observed in a young baby might be the consequence of drug withdrawal. The absence of a positive maternal drug history in no way negates this diagnostic possibility. Although opiate withrawal is the subject of this paper, combinations of drugs are commonly involved and there may sometimes b...

OBJECTIVES To identify simple long term predictors of maintenance of normotension after withdrawal of antihypertensive drugs in elderly patients in general practice. DESIGN Prospective cohort study. SETTING 169 general practices in Victoria, Australia. PARTICIPANTS 503 patients aged 65-84 with treated hypertension who were withdrawn from all antihypertensive drugs and remained drug free a...

A term baby was admitted to our neonatal unit with jitteriness, hypertonia, sneezing and fever. Her mother was on 20 mg of fluoxetine throughout her pregnancy. These symptoms which were possibly due to fluoxetine withdrawal lasted only for a short while. We attempt to look at the reported prevalence of this condition in the literature.