Altered lipid metabolism is increasingly recognized as a signature of cancer cells. Enabled by label-free Raman spectromicroscopy, we performed quantitative analysis of lipogenesis at single-cell level in human patient cancerous tissues. Our imaging data revealed an unexpected, aberrant accumulation of esterified cholesterol in lipid droplets of high-grade prostate cancer and metastases. Bioche...

Digitally enhanced heterodyne interferometry is a laser metrology technique employing pseudo-random codes phase modulated onto an optical carrier. We present the first characterization of the technique's displacement sensitivity. The displacement of an optical cavity was measured using digitally enhanced heterodyne interferometry and compared to a simultaneous readout based on conventional Poun...

The relationship between agile methods and Software Engineering Institute’s CMM approach is often debated. Some authors argue that the approaches are compatible, while others have criticized the application of agile methods from the CMM perspective. Only few CMM based assessments have been performed on projects using agile approaches. This paper explores an empirical case where a project using ...

⎯ Checkpointing schemes facilitate fault recovery in distributed systems. The two-level fault recovery scheme of distributed system inherits the merits of both disk-based and diskless checkpointing schemes. The present work extends James S Plank’s Diskless checkpointing scheme (N+1 Parity) by introducing ‘Timeout’ to checkpoint programs with high locality of reference. This mechanism enables ap...

PETRI NETS, WHICH CAN ANALYZE systems involving conditional relationships, provide straightforward models for rulebased systems.1 Researchers have used Petrinet models to study knowledge validation, verification, and testing.2–4 However, these models considered a rule-based system to consist of rules that are explicitly described; that is, no variables appear in the rule bodies. Moreover, these...

objective(s): in this study, we aimed to describe the characteristics of portal vein tumor thrombosis (pvtt), complicating hepatocellular carcinoma (hcc) in contrast-enhanced fdg pet/ct scan. methods: in this retrospective study, 9 hcc patients with fdg-avid pvtt were diagnosed by contrast-enhanced fluorodeoxyglucose positron emission tomography/computed tomography (fdg pet/ct), which is a comb...