This research is to evaluate the acute and subchronic toxicities of “Kien ty chi thong - HV” granules through oral administration in experimental animals. The toxicity was determined by Litchfield Wilcoxon method Swiss mice. evaluated WHO OECD’s recommendation Wistar rats with doses 1.8 g/kg/day (equal recommended human dose) 5.4 (3 times as high 4 consecutive weeks. As a result, at highest dos...

The hedonic component of the feeding behavior involves the mesolimbic reward system and resembles addictions. Nowadays, the excessive consumption of sucrose is considered addictive. The Wistar-Kyoto (WKY) rat strain is prone to develop anxiety and addiction-like behavior; nevertheless, a lack of information regarding their vulnerability to develop sugar binging-like behavior (SBLB) and how it a...

Coconut juice is a natural drink from coconut fruit. This study was aimed at evaluating its positive potential on biochemical indices. Fresh fruits were de-dshelled and washed. The cotyledon broken to extract the water which used in blending fruits. filtered filtrate collected vial. Twenty healthy male Wistar rats weighing 160 -180 g, grouped into two groups of ten each treated as follows for f...

Because angiotensin (Ang) metabolites mediate functions independent of Ang II, we investigated their effects on coronary flow in spontaneously hypertensive rats (SHRs). Results were compared with those in the iliac artery and abdominal aorta and the coronary circulation of the Wistar rat. Ang II, III, and IV decreased coronary flow in SHRs and Wistar rats, with Ang III and IV being approximatel...

The present study is a contribution to the enhancement of Ivorian traditional medicine, by carrying out bio-tolerance tests an aqueous extract aerial parts Crotalaria retusa (EACr) in mice and rats according guidelines Organization for Economic Co-operation Development (OECD) 423 407, respectively. doses 2000 5000 mg/kg body weight (BW) were used acute toxicity. For subacute toxicity which last...

OBJECTIVES Tension cost, the ratio of myosin ATPase activity to tension, reflects the economy of tension development in the myocardium. To evaluate the mechanical advantage represented by the tension cost, we studied papillary muscle contractility and the activity of myosin ATPase in the left ventricles in normal and pathophysiological conditions. METHODS Experimental protocols were performed...

Hyperglycemia in Diabetes mellitus (DM) induces oxidative stress and mitochondrial disruptions the liver, thereby triggering apoptosis through Bcl-2 family signaling. Excessive leads to liver dysfunction. Chlorogenic acid (CGA) was elucidated this study preventing dysfunction as a progression of DM. The diabetic model conducted Wistar rats, divided into six groups. Blood examinations were done ...

Abstract The effectiveness of calcium depends on its source, i.e., salt it is supplied with. This study aimed to determine the effects lactate in diet inflammation and oxidative stress markers ovariectomized rats. A total 40 female Wistar rats were included this study, which divided into four groups. control group was fed a standard diet, whereas remaining three groups provided containing carbo...

The objective of this study was to evaluate the antioxidant properties Senna siamea and their effects on sports performance in rats. A total 15 male Wistar rats were used divided into 3 groups. GrpEDSE GrpED+Entr groups each subjected 7 mL/kg distilled water by body weight, then GrpSS+Entr group treated with 300 mg/kg weight aqueous extract leaves. Rats belonging GrpED+Entr, swimming for fiftee...

For better understanding of pathophysiological processes leading to increased retention of sodium as a consequence of hyperlipidemia, the properties of renal Na,K-ATPase, a key enzyme involved in maintaining sodium homeostasis in the organism, were studied. Enzyme kinetics of renal Na,K-ATPase were used for characterization of ATP- and Na(+)-binding sites after administration of fish oil (FO) (...