Lithium (Li), a glycogen synthase kinase-3β (GSK-3β) inhibitor, has used to attenuate thecannabinoid-induced dependence/withdrawal signs, but molecular mechanisms related to this areunclear. Recent studies indicate the involvement of upstream extracellular signal kinase1/2 (ERK1/2)and downstream GSK-3β pathways in the development of cannabinoid-induced dependence. Thisis mediated through cannab...

Lithium (Li), a glycogen synthase kinase-3β (GSK-3β) inhibitor, has used to attenuate thecannabinoid-induced dependence/withdrawal signs, but molecular mechanisms related to this areunclear. Recent studies indicate the involvement of upstream extracellular signal kinase1/2 (ERK1/2)and downstream GSK-3β pathways in the development of cannabinoid-induced dependence. Thisis mediated through cannab...

Abstract Phototherapy usually includes photodynamic therapy (PDT) and photothermal (PTT) to induce cell death. PDT utilizes the sensitization of photosensitizers generate reactive oxygen species by intersystem crossing while PTT undergoes nonradiative decay heat. Cancer immunotherapy has evolved as a new therapeutic modality eradicate tumor cells activating antigen-presenting cells, thus, induc...

Large archives of astronomical data (images, spectra and catalogues of derived parameters) are being assembled worldwide as part of the Virtual Observatory project. In order for such massive heterogeneous data collections to be of use to astronomers, development of Computational Intelligence techniques that would combine modern machine learning with deep domain knowledge is crucial. Both fields...

Women wishing to combine children with a research career should not be seen as taking a backstep but as bolstering both activities, argues Marlene Belfort.

Traditional systems development research largely adopts a negative view and focuses on failures. In contrast, this study adopts a positive approach to improve current practices. We report from an action research project at a small software firm, TelSoft, in which we applied appreciative inquiry to develop information technology (IT) project management skills. The inquiry process offers two cont...

A major trend in mobile advertising is the emergence of real time bidding (RTB) based marketplaces on the supply side and the corresponding programmatic impression buying on the demand side. In order to acquire the most relevant audience impression at the lowest cost, a demand side player has to accurately estimate the win rate and winning price in the auction, and incorporate that knowledge in...